If you’re looking to diminish the appearance of wrinkles, using the right serums in your skincare routine is key. Here are some of the best serums for wrinkles.

1. AHA 8% Peeling Serum

Mizon Serum for Exfoliating and Reducing the Signs of Aging

Mizon AHA 8% Peeling Serum

This exfoliating serum combines the power of glycolic acid with other calming ingredients to reveal a smoother skin tone and texture while soothing the skin.

Skin types: All Skin Types
Best for: Exfoliating and Reducing the Signs of Aging
Tested on animals: No
How to use: After cleansing, massage the product into the skin. Follow up with a moisturizer.
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This serum contains an 8% concentration of glycolic acid, an alpha hydroxy acid (AHA). Glycolic acid improves skin tone and texture while minimizing signs of aging.

Pros

  • Contains soothing ingredients to counteract irritation
  • Exfoliating

Cons

  • Contains fragrance

In addition to the glycolic acid, this serum contains a variety of ingredients that hydrate and soothe the skin, including aloe, allantoin, castor oil, centella asiatica (tiger grass) extract, and papaya fruit extract.

Water, Glycolic Acid, Potassium Hydroxide, Butylene Glycol, Propylene Glycol, Sodium Lactate, Hydroxyethylcellulose, Sodium Hyaluronate, PEG-60 Hydrogenated Castor Oil, Panthenol, Allantoin, Aloe Barbadensis (Aloe Vera) Leaf Extract, Portulaca Oleracea (Green Purslane) Extract, Carica Papaya (Papaya) Fruit Extract, Arnica Montana (Arnica) Flower Extract, Artemisia Absinthium (Mugwort) Extract, Achillea Millefolium (Common Yarrow) Extract, Gentiana Lutea (Yellow Gentian) Root Extract, Alcohol, Polyquaternium-10, Disodium EDTA, Methylparaben, Propylparaben, Fragrance

2. Buffet Serum

The Ordinary Serum for Fighting the Signs of Aging

The Ordinary “Buffet”

“Buffet” is a multi-purpose serum that combines a variety of peptide complexes, amino acids, and hyaluronic acids to address signs of aging.

Skin types: All Skin Types
Best for: Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Peptides are excellent for reducing wrinkles, improving the skin’s barrier, and promoting skin elasticity. This gel-like serum from The Ordinary pulls out all the stops with six peptide complexes for potent anti-aging benefits.

Pros

  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

In addition to the peptide complexes, this serum contains 11 amino acids that help increase the skin’s hydration and further fight the signs of aging. It also contains multiple hyaluronic acid complexes, which attract moisture to the skin and reduce the appearance of fine lines.

Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

3. 10% Pure Vitamin C Serum

La Roche-Posay Serum for Hyperpigmentation and Wrinkles

La Roche-Posay 10% Pure Vitamin C Serum

This serum contains a potent concentration of vitamin C, which is known for its ability to brighten, diminish post-inflammatory hyperpigmentation, and even skin tone.

Skin types: All Skin Types
Best for: Hyperpigmentation and Wrinkles
Tested on animals: Yes
How to use: After cleansing, apply the serum all over the face, neck, and chest.
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Vitamin C is an incredibly effective skincare ingredient that is known to boost collagen production, which in turn brightens, fades hyperpigmentation, and diminishes fine lines and wrinkles. This serum contains a potent 10% concentration of vitamin C (ascorbic acid), which will help even overall skin tone and texture.

Pros

  • Oil-free
  • Dermatologist tested

Cons

  • Contains fragrance

In addition to ascorbic acid, this serum contains salicylic acid, which gently exfoliates, and hyaluronic acid and sodium hyaluronate, which draw moisture to the skin.

Aqua/Water/Eau, Ascorbic Acid, Cyclohexasiloxane, Glycerin, Alcohol Denat., Potassium Hydroxide, Polymethylsilsesquioxane, Polysilicone-11, Dimethicone, Propylene Glycol, Pentaerythrityl Tetraethylhexanoate, C13-14 Isoparaffin, Tocopherol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Adenosine, Acetyl Dipeptide-1 Cetyl Ester, Peg-20 Methyl Glucose Sesquistearate, Poloxamer 338, Salicylic Acid, Polyacrylamide, Toluene Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Bht, Laureth-7, Parfum/Fragrance.

  1. National Center for Biotechnology Information. "The Roles of Vitamin C in Skin Health"

    Accessed Aug. 16, 2021.

4. Vitamin C Suspension 23% + HA Spheres 2%

The Ordinary Serum for Evening Skin Tone and Fighting the Signs of Aging

The Ordinary Vitamin C Suspension 23% + HA Spheres 2%

This is one of the best The Ordinary products to add to your skincare routine, because it contains a potent concentration of vitamin C (ascorbic acid), which brightens and evens out overall skin tone while fighting the signs of aging.

Skin types: All Skin Types
Best for: Evening Skin Tone and Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Those looking to brighten their skin tone while also fighting against the signs of aging should turn to this product, which has the highest concentration of antioxidant-rich vitamin C of any of the products the brand offers. Since vitamin C has been shown to help with hyperpigmentation, this option is also great for those looking to even out dark spots. In addition to vitamin C, this product contains sodium hyaluronate (the sodium salt of hyaluronic acid), which increases moisture in the skin.

Pros

  • Oil-free
  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

Since this product contains such a high percentage of vitamin C, some users may experience tingling as their skin adjusts, particularly if they’re newer to topical vitamin C.

Ascorbic Acid, Squalane, Isodecyl Neopentanoate, Isononyl Isononanoate, Coconut Alkanes, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Sodium Hyaluronate, Glucomannan, Coco-Caprylate/Caprate, Butylene/Ethylene/Styrene Copolymer, Acrylates/Ethylhexyl Acrylate Crosspolymer, Trihydroxystearin, BHT.

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Aug. 11, 2021.

5. 20% Vitamin C + E Ferulic Acid Serum

Timeless Serum for Brightening and Anti-Aging

Timeless 20% Vitamin C + E Ferulic Acid Serum

This affordable vitamin C serum contains a 20% concentration of vitamin C, which helps brighten and fight signs of aging.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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This lightweight serum contains a 20% concentration of l-ascorbic acid, a form of vitamin C that works to brighten and provide anti-aging benefits. It also contains vitamin E and ferulic acid, two skincare ingredients that protect the skin from environmental stressors and have also been shown to increase the efficacy of vitamin C.

Pros

  • Lightweight
  • Affordable
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some reviewers complain about the pump

In addition to the ingredients mentioned above, this serum contains hyaluronic acid, which attracts moisture to the skin to keep it hydrated.

Water, Ethoxydiglycol, L-Ascorbic Acid, Propylene Glycol, Alpha Tocopherol, Polysorbate 80, Panthenol, Ferulic Acid, Sodium Hyaluronate, Benzylalcohol, Dehydroacetic Acid

  1. National Center for Biotechnology Information. "Vitamin C in Dermatology"

    Accessed Aug. 31, 2021.

6. Vitamin C Serum

TruSkin Serum for Brightening and Anti-Aging

TruSkin Vitamin C Serum

This gentle and affordable serum contains vitamin C, which brightens and fights signs of aging, as well as other soothing and hydrating skincare ingredients.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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This vitamin C serum contains sodium ascorbyl phosphate, a stable form of vitamin C that helps brighten and provide anti-aging benefits. It also contains hyaluronic acid, which attracts moisture to the skin, and vitamin E, an antioxidant that protects against free radical damage to the skin.

Pros

  • Affordable
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some acne-prone reviewers noted that it broke them out

In addition to the ingredients mentioned above, this serum contains jojoba oil, which moisturizes, and witch hazel, which soothes.

Organic Deionized Herbal Infusion, Organic Aloe Barbadensis Leaf (Aloe), Sodium Ascorbyl Phosphate (Vitamin C), MSM, Botanical Hyaluronic Acid (Cassia Angustifolia Seed Polysaccharide), Hamamelis Virginiana (Witch Hazel), Vitamin E (d-alpha Tocopheryl Acetate), Carbomer, (2s)-2-Amino-5-guanidinopentanoic Acid, Organic Gotu Kola, Wildcrafted Horsetail (Equisetum Arvense), Wildcrafted Dandelion, Wildcrafted Geranium, Organic Jojoba Oil (Organic Simmondsia Chinensis), Phenoxyethanol, Ethyl Hexyl Glycerin.

  1. National Center for Biotechnology Information. "Sodium ascorbyl phosphate in topical microemulsions"

    Accessed Aug. 31, 2021.
  2. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Aug. 31, 2021.

7. Vitamin C Concentrated Serum

Derma E Serum for Brightening and Anti-Aging

Derma E Vitamin C Concentrated Serum

This affordable vitamin C serum contains a stable and effective form of vitamin C, as well as additional ingredients that help hydrate and soothe the skin.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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Vitamin C – an antioxidant that fights free radicals that can damage the skin – is key for a rounded out skincare routine, and this option is affordable and effective. It contains sodium ascorbyl phosphate, a stable form of vitamin C that doesn’t deteriorate as easily as other forms. It is able to brighten the skin and fight signs of aging, including fine lines, wrinkles, and dark spots.

Pros

  • Affordable
  • Lightweight
  • Vegan and cruelty-free

Cons

  • Contains fragrance

In addition to vitamin C, this serum contains a blend of ingredients that hydrate, soothe, and nourish the skin, including hyaluronic acid, green tea leaf extract, rosehip oil, and aloe vera extract.

Purified Water, Glycerin (Vegetable Derived), Sodium Ascorbyl Phosphate (Vitamin C, Stay-C 50), Sodium Hyaluronate (Hyaluronic Acid), Organic Camellia Sinensis (Green Tea) Leaf Extract*, Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Alpha-Glucan Oligosaccharide (Vegetable Derived), Polymnia Sonchifolia (Yacon) Root Juice, Maltodextrin, Lactobacillus (Probiotic), Rosa Canina (Rosehip) Fruit Oil, Organic Aloe Barbadensis (Aloe Vera) Extract *, Allantoin, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Caprylic/Capric Triglyceride (Plant Derived), Ethylhexyl Palmitate, Xanthan Gum, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils

  1. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Aug. 31, 2021.
  2. National Center for Biotechnology Information. "Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies"

    Accessed Aug. 31, 2021.
  3. National Center for Biotechnology Information. "Sodium ascorbyl phosphate in topical microemulsions"

    Accessed Aug. 31, 2021.

8. C15 Super Booster

Paula's Choice Serum for Brightening and Fighting Signs of Aging

C15 Super Booster

The 15% concentration of pure vitamin C in this serum helps brighten the skin while reducing the appearance of fine lines and wrinkles.

Skin types: All Skin Types
Best for: Brightening and Fighting Signs of Aging
Tested on animals: No
How to use: Massage two to three drops of the serum into clean skin. Follow up with a moisturizer.
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This lightweight serum is one of the best Paula’s Choice products, as it contains a powerful concentration of vitamin C, which evens out and brightens the skin tone while also minimizing fine lines and wrinkles. It also contains ingredients that hydrate and soothe the skin.

Pros

  • Fragrance-free
  • Lightweight
  • Non-greasy

Cons

  • May irritate more sensitive skin types

In addition to vitamin C, this serum contains ferulic acid and vitamin E. These antioxidants protect the skin, and are also known to increase the efficacy of vitamin C.

Water (Aqua), Ascorbic Acid (vitamin C/antioxidant), Butylene Glycol (solvent/texture enhancer), Ethoxydiglycol (solvent/texture enhancer), Glycerin (skin-replenishing), PPG-26-Buteth-26 (emulsifier/skin-softening), PEG-40 Hydrogenated Castor Oil (emulsifier/solubility enhancer), Pentylene Glycol (skin-softening slip agent), Tocopherol (vitamin E/stabilizing antioxidant), Sodium Hyaluronate (hydration), Hexanoyl Dipeptide-3 Norleucine Acetate (skin-restoring peptide), Lecithin (skin-restoring/hydration), Ferulic Acid (stabilizing antioxidant), Panthenol (vitamin B5/skin-softening, skin-soothing), Bisabolol (skin-soothing), Oryza Sativa (Rice) Bran Extract (skin-softening/chelating agent), Propyl Gallate (antioxidant), Sodium Gluconate (chelating agent), Sodium Hydroxide (pH adjuster), Phenoxyethanol (preservative), Ethylhexylglycerin (preservative)

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Jul. 30, 2021.

9. C-Firma Vitamin C Day Serum

Drunk Elephant Serum for Fading Hyperpigmentation and Anti-Aging

Drunk Elephant C-Firma Vitamin C Day Serum

This serum contains a potent concentration of vitamin C, which is excellent for brightening and lightening post-inflammatory hyperpigmentation, as well as fighting the signs of aging.

Skin types: All Skin Types
Best for: Fading Hyperpigmentation and Anti-Aging
Tested on animals: No
How to use: Massage the serum into the face, neck, and chest. Follow up with a moisturizer, as well as SPF during the day.
See on Amazon

This serum contains a 15% concentration of vitamin C (l-ascorbic acid), which promotes the production of collagen. This in turn helps minimize the appearance of hyperpigmentation, while also providing anti-aging benefits. It also contains antioxidant-rich ferulic acid and vitamin E, which protect the skin from environmental stressors, and have also been shown to increase the efficacy of vitamin C.

Pros

  • Fragrance-free
  • Lightweight
  • Cruelty-free

Cons

  • Some reviewers complain about the smell

In addition to the blend of vitamin C, vitamin E, and ferulic acid, this serum contains pumpkin ferment and pomegranate extract, which dissolve skin cells on the surface of the skin for even, smooth skin.

Water/Aqua/Eau, Dimethyl Isosorbide, Ascorbic Acid, Laureth-23, Glycerin, Lactobacillus/Pumpkin Ferment Extract, Sclerocarya Birrea Seed Oil, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra (Licorice) Root Extract, Vitis Vinifera (Grape) Juice Extract, Phyllanthus Emblica Fruit Extract, Camellia Sinensis Leaf Extract, Tocopherol, Lactobacillus/Punica Granatum Fruit Ferment Extract, Sodium Hyaluronate Crosspolymer, Hydrolyzed Quinoa, Phytosterols, Glutamylamidoethyl Imidazole, Hydrolyzed Wheat Protein, Ferulic Acid, Acetyl Glucosamine, Sodium Hyaluronate, Tetrahydrobisdemethoxydiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrodiferuloylmethane, Glycine, Leuconostoc/Radish Root Ferment Filtrate, Sucrose, Maltodextrin, Chondrus Crispus Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Phenoxyethanol, Caprylhydroxamic Acid, Caprylyl Glycol, Sorbitan Isostearate, Propanediol, Pentylene Glycol, Xanthan Gum, Butylene Glycol, Sodium Hydroxide, Chlorphenesin, Polysorbate 60, Sodium Dehydroacetate, Potassium Sorbate, Sorbic Acid, Ethylhexylglycerin

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Jul. 30, 2021.

FAQs

What is the best serum for deep wrinkles?

If you’re dealing with deep wrinkles, you may want to look into adding a retinol to your skincare routine, in addition to one (or a few) of the serums mentioned above. You may also want to talk to a dermatologist about deep wrinkle treatments (such peels, dermabrasion, and laser treatments) that can be done in a medical setting. Adding anti-aging ingredients like vitamin C, AHAs, and peptides to your routine can certainly help minimize the appearance of lines, but deeper wrinkles may also require a retinol product and/or a professional treatment for the best results.

Which is better for wrinkles: retinol or hyaluronic acid?

Hyaluronic acid pulls moisture to the skin to keep it hydrated, and it has been shown to help soften the appearance of fine lines and wrinkles. However, retinol is the gold standard for anti-aging, and is the more effective ingredient when it comes to fighting wrinkles. That said, both of these skincare ingredients can be used in your routine for maximum anti-aging results. Hyaluronic acid and retinol products can also be layered together.

Can you reverse deep wrinkles?

With the right treatment, deep wrinkles can be reversed. Retinol, vitamin C, AHAs, and peptides are all great ingredients to use in an anti-aging skincare routine, and can help smooth the appearance of wrinkles. However, if you’re looking to reverse deep wrinkles, you may need a treatment from a medical professional.

The Bottom Line

If you want to soften lines and prevent new ones from forming, these are some of the best serums for wrinkles. Consider adding some of these products to your medicine cabinet for a well-rounded anti-aging skincare routine.