If you’re looking to diminish the appearance of wrinkles, using the right serums in your skincare routine is key. Here are some of the best serums for wrinkles.

Our Recommendations

1. The Glow Maker Antioxidant Serum

Maelove The Glow Maker Antioxidant Serum

Maelove Serum for Brightening and Anti-Aging

Maelove The Glow Maker Antioxidant Serum

This lightweight and oil-free vitamin C serum from Maelove combines vitamin C with other powerful ingredients to fight signs of aging, brighten, and hydrate the skin.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply an even layer of the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
See on Amazon

This affordable vitamin C serum contains a 15% concentration of l-ascorbic acid (a form of vitamin C), which works to minimize signs of aging, promote a more even skin tone, and brighten the complexion. It also contains vitamin E and ferulic acid, two antioxidant-rich ingredients that have been proven to increase the efficacy of vitamin C. The Glow Maker also features hyaluronic acid, which helps hydrate the skin.

Pros

  • Anti-aging and brightening
  • Lightweight
  • Oil-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some reviewers complain that the serum oxidizes easily (keep in the fridge to maintain integrity of the formula)

This lightweight serum contains a botanical blend that helps soothe and nourish the skin. It includes aloe, magnolia, and vitis vinifera.

Water (Aqua), Ascorbic Acid, Ethoxydiglycol, Aloe Barbadensis Leaf Juice, Glycerin, Lecithin, Sodium Hyaluronate, Ferulic Acid, Citrus Aurantium Dulcis (Orange) Callus Culture Extract, Magnolia Officinalis Bark Extract, Vitis Vinifera (Grape) Seed Extract, Xanthan Gum, Disodium EDTA, Sodium Metabisulfite, Triethanolamine, Phenoxyethanol, Ethylhexyglycerin, Maltodextrin, Tocopherol

  1. National Center for Biotechnology. "Vitamin C in dermatology"

    Accessed Jan. 27, 2022.

2. Vitamin C Serum with Ferulic Acid, Vitamin E, and

Dr. Brenner Vitamin C Serum

Dr. Brenner Serum for Brightening and Anti-Aging

Dr. Brenner Vitamin C Serum with Ferulic Acid, Vitamin E, and Hyaluronic Acid

This affordable vitamin C serum combines l-ascorbic acid (a form of vitamin C) with other potent ingredients to brighten, even skin tone, increase firmness, and fight against signs of aging.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply an even layer of the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
See on Amazon

This is an excellent product for those looking for a budget-friendly, fragrance-free vitamin C serum. It contains a 20% concentration of vitamin C, which works to fight signs of aging and even skin tone while defending against damaging oxidative stress. The formula also contains antioxidant-rich vitamin E and ferulic acid, which have been proven to increase the efficacy of vitamin C.

Pros

  • Anti-aging and brightening
  • Affordable
  • Vegan and cruelty-free
  • Fragrance-free
  • Dermatologist developed

Cons

  • Some reviewers complain that it feels sticky on the skin

In addition to the ingredients mentioned above, this vegan and cruelty-free vitamin C serum contains hyaluronic acid, which helps attract moisture to the skin and lock it in for a plump and hydrated complexion.

Water, Ethoxydiglycol, L-Ascorbic Acid (Vitamin C) 20%, Propylene Glycol, Glycerin, Laureth-23, Tocopherol (Vitamin E) 1%, Sodium Hyaluronate (Hyaluronic Acid ) 1%, Ferulic Acid .5%, Panthenol, Triethanolamine, Phenoxyethanol

  1. National Center for Biotechnology. "Vitamin C in dermatology"

    Accessed Jan. 27, 2022.

3. Hyaluronic Acid

The Inkey List Serum for Hydration

The Inkey List Hyaluronic Acid

This affordable serum uses the power of hyaluronic acid and other potent ingredients to hydrate, plump, and smooth the skin.

Skin types: All Skin Types
Best for: Hydration
Tested on animals: No
How to use: After cleansing, apply an even layer of the serum all over the face. Follow up with a moisturizer, and sunscreen during the day.
See on Sephora

Hyaluronic acid is a super effective skincare ingredient that attracts and locks in moisture to maintain the skin’s hydration levels. This hydrating serum is formulated with multiple molecular weight hyaluronic acid, which is able to hydrate different layers of the skin. It’s an excellent choice for those looking for a budget-friendly hydrating serum.

Pros

  • Lightweight
  • Hydrating
  • Affordable
  • Vegan and cruelty-free
  • Fragrance-free
  • Non-toxic

Cons

  • Some reviewers note that it can feel slightly sticky on the skin

In addition to the hyaluronic acid, this serum contains a Matrxyl 3000 peptide, which supports the skin’s natural collagen production and minimizes the appearance of fine lines and wrinkles.

Water, Propanediol, Glycerin, Butylene Glycol, Sodium Hyaluronate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Leuconostoc/Radish Root Ferment Filtrate, Hyaluronic Acid, Carbomer, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Phenoxyethanol

  1. National Center for Biotechnology Information. "Hyaluronic acid: A key molecule in skin aging"

    Accessed Jan. 12, 2022.

4. Vitamin C Serum

Mad Hippie Serum for Anti-aging and brightening

Mad Hippie Vitamin C Serum

This natural vitamin C serum contains sodium ascorbyl phosphate (a stable form of vitamin C) and other effective skincare ingredients to help brighten, hydrate, and provide anti-aging benefits.

Skin types: All Skin Types
Best for: Anti-aging and brightening
Tested on animals: No
How to use: After cleansing, apply four to five drops of the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
See on Amazon

This effective yet affordable vitamin C serum contains antioxidant-rich vitamin E and ferulic acid, which have been shown to increase the efficacy of vitamin C. It is also packed with additional ingredients that help hydrate, soften, and smooth the skin, including konjac root and hyaluronic acid.

Pros

  • Natural
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some reviewers noted it felt sticky on the skin

In addition to the ingredients mentioned above, this vegan and cruelty-free vitamin C serum contains chamomile, grapefruit, and clary sage, which provide antioxidant protection and calm the skin.

Water Deionized, Vitamin C (Sodium Ascorbyl Phosphate), Alkyl Benzoate, Vegetable Glycerin, Water, Glycerin, Sodium Levulinate, Sodium Anisate, Clary Sage (Salvia Sclarea), Grapefruit (Citrus Grandis), Hyaluronic acid, Amorphophallus Konjac Root Powder, Aloe Barbadensis Leaf, Vitamin E (Tocotrienol), Ferulic acid, Chamomile Flower Extract (Recutita Matricaria), Sodium Phytate, Xanthan Gum, Hydroxyethylcellulose

  1. National Center for Biotechnology. "Vitamin C in dermatology"

    Accessed Nov. 11, 2021.

5. C E Ferulic with 15% L-Ascorbic Acid

SkinCeuticals C E Ferulic with 15% L-Ascorbic Acid

SkinCeuticals Serum for Anti-aging and brightening

SkinCeuticals C E Ferulic with 15% L-Ascorbic Acid

This brightening and anti-aging vitamin C serum is often considered one of the best of the best. It helps improve signs of aging while fighting environmental aggressors.

Skin types: Normal, Dry, Combination and Sensitive
Best for: Anti-aging and brightening
Tested on animals: Yes
How to use: After cleansing, apply four to five drops of the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
See on Amazon

This fragrance-free vitamin C serum contains a potent 15% concentration of l-ascorbic acid, a form of vitamin C that helps neutralize free radicals, defend against oxidative stress, and brighten and fight signs of aging. It is formulated with antioxidant-rich vitamin E and ferulic acid, which both further protect against environmental stressors. These ingredients have also been shown to increase the efficacy of vitamin C.

Pros

  • Anti-aging
  • Brightening
  • Fragrance-free

Cons

  • Expensive
  • Some reviewers complain about the smell

This anti-aging serum remains effective for at least 72 hours after being absorbed into the skin. It also contains additional ingredients that help hydrate the skin, including glycerin and sodium hyaluronate.

Water, Ethoxydiglycol, L-Ascorbic Acid, Propylene Glycol, Glycerin, Laureth-23, Alpha Tocopherol, Phenoxyethanol, Triethanolamine, Ferulic Acid, Panthenol, Sodium Hyaluronate

  1. National Center for Biotechnology. "Vitamin C in dermatology"

    Accessed Nov. 9, 2021.

6. Resurfacing Retinol Serum

CeraVe Resurfacing Retinol Serum

CeraVe Serum for Fading post-inflammatory hyperpigmentation and minimizing large pores

CeraVe Resurfacing Retinol Serum

This drugstore retinol serum is specifically formulated to tackle post-inflammatory hyperpigmentation and large pores, and helps promote an overall even and clear complexion.

Skin types: Normal, Oily and Combination
Best for: Fading post-inflammatory hyperpigmentation and minimizing large pores
Tested on animals: Yes
How to use: After cleansing, apply a pump of the serum evenly all over the face, neck, and chest. Use once a day (or less frequently to prevent irritation).
See on Amazon

This is an excellent choice for those looking for an affordable retinol. This fragrance-free retinol serum not only helps with acne scars and large pores, but it can also help fight signs of aging and brighten the skin.

Pros

  • Affordable
  • Lightweight
  • Non-comedogenic
  • Fragrance-free
  • Developed with dermatologists

Cons

  • May cause irritation or dryness

This non-comedogenic retinol serum also contains ceramides and niacinamide, which work to calm and restore the skin while maintaining its barrier. Additionally, this formula contains licorice root extract, which gives a brightening boost. That extra benefit may further help lighten discolored scars.

Aqua/Water, Propanediol, Dimethicone, Cetearyl Ethylhexanoate, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Dipotassium Glycyrrhizate, Hydrogenated Lecithin, Potassium Phosphate, Ceramide Np, Ceramide Ap, Ceramide Eop, Carbomer, Cetearyl Alcohol, Behentrimonium Methosulfate, Dimethiconol, Lecithin, Sodium Citrate, Retinol, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Cholesterol, Phenoxyethanol, Alcohol, Isopropyl Myristate, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Pentylene Glycol, Phytosphingosine, Xanthan Gum, Polysorbate 20, Ethylhexylglycerin

  1. National Center for Biotechnology Information. "Why Topical Retinoids Are Mainstay of Therapy for Acne"

    Accessed Nov. 8, 2021.
  2. National Center for Biotechnology Information. "How Much Do We Really Know About Our Favorite Cosmeceutical Ingredients?"

    Accessed Nov. 8, 2021.
  3. National Center for Biotechnology Information. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products"

    Accessed Nov. 8, 2021.

7. AHA 8% Peeling Serum

Mizon AHA 8% Peeling Serum

Mizon Serum for Exfoliating and Reducing the Signs of Aging

Mizon AHA 8% Peeling Serum

This exfoliating serum combines the power of glycolic acid with other calming ingredients to reveal a smoother skin tone and texture while soothing the skin.

Skin types: All Skin Types
Best for: Exfoliating and Reducing the Signs of Aging
Tested on animals: No
How to use: After cleansing, massage the product into the skin. Follow up with a moisturizer.
See on Amazon

This serum contains an 8% concentration of glycolic acid, an alpha hydroxy acid (AHA). Glycolic acid improves skin tone and texture while minimizing signs of aging.

Pros

  • Contains soothing ingredients to counteract irritation
  • Exfoliating

Cons

  • Contains fragrance

In addition to the glycolic acid, this serum contains a variety of ingredients that hydrate and soothe the skin, including aloe, allantoin, castor oil, centella asiatica (tiger grass) extract, and papaya fruit extract.

Water, Glycolic Acid, Potassium Hydroxide, Butylene Glycol, Propylene Glycol, Sodium Lactate, Hydroxyethylcellulose, Sodium Hyaluronate, PEG-60 Hydrogenated Castor Oil, Panthenol, Allantoin, Aloe Barbadensis (Aloe Vera) Leaf Extract, Portulaca Oleracea (Green Purslane) Extract, Carica Papaya (Papaya) Fruit Extract, Arnica Montana (Arnica) Flower Extract, Artemisia Absinthium (Mugwort) Extract, Achillea Millefolium (Common Yarrow) Extract, Gentiana Lutea (Yellow Gentian) Root Extract, Alcohol, Polyquaternium-10, Disodium EDTA, Methylparaben, Propylparaben, Fragrance

8. Hyaluronic Acid Booster

Paula’s Choice Hyaluronic Acid Booster

Paula's Choice Serum for Hydration

Paula’s Choice Hyaluronic Acid Booster

This serum combines hyaluronic acid with ceramides and other deeply hydrating ingredients to give the skin an extra moisture boost.

Skin types: All Skin Types
Best for: Hydration
Tested on animals: No
How to use: Massage a pump of the serum into clean skin. Follow up with a moisturizer.
See on Amazon

Hyaluronic acid is a great skincare ingredient for all skin types, because it pulls moisture to the skin to help it maintain healthy hydration levels. The ceramides in this booster also help restore the moisture barrier and strengthen the skin.

Pros

  • Fragrance-free
  • Lightweight

Cons

  • May irritate sensitive skin

In addition to the hydrating benefits, hyaluronic acid has been shown to help minimize the appearance of fine lines and wrinkles, making this booster a great choice for those looking for anti-aging benefits.

Water (Aqua), Glycerin (hydration/skin replenishing), Sodium Hyaluronate (hydration/skin replenishing), Hyaluronic Acid (hydration/skin replenishing), Ceramide NP (hydration/skin replenishing), Ceramide AP (hydration/skin replenishing), Ceramide EOP (hydration/skin replenishing), Phytosphingosine (hydration/skin replenishing), Yeast Extract (skin replenishing), Adenosine (skin-restoring), Cholesterol (skin replenishing), Panthenol (skin replenishing), Silanetriol (hydration), Butylene Glycol (hydration), Sodium Lauroyl Lactylate (hydration), Carbomer (texture-enhancing), Xanthan Gum (texture-enhancing), Citric Acid, Sodium Hydroxide, Polysorbate 20 (texture-enhancing), Ethylhexylglycerin (preservative), Phenoxyethanol (preservative)

9. Moisture Renewal Oil Booster

Paula’s Choice Moisture Renewal Oil Booster

Paula's Choice Serum for Extra Moisture

Paula’s Choice Moisture Renewal Oil Booster

This oil booster contains a blend of nourishing plant oils and renewing ceramides to help moisturize and revitalize dry skin.

Skin types: All Skin Types
Best for: Extra Moisture
Tested on animals: No
How to use: Massage a few drops into clean skin. Follow up with a moisturizer.
See on Amazon

This customer favorite booster contains nine non-fragrant, antioxidant-rich plant oils that alleviate dryness and calm the skin. It also contains ceramides, which further help restore the moisture barrier of the skin.

Pros

  • Fragrance-free
  • Non-irritating

Cons

  • Some reviewers note it feels greasy on the skin

One of the key oils in this booster is jojoba oil, which is anti-inflammatory, can help restore the skin’s barrier, and has the ability to help fight the signs of aging. Another key ingredient in this blend is argan oil, a skin-softening oil that has been shown to improve elasticity and hydration.

Simmondsia Chinensis (Jojoba) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Carthamus Tinctorius (Safflower) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Prunus Armeniaca (Apricot) Kernel Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Helianthus Annuus (Sunflower) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Vaccinium Macrocarpon (Cranberry) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Argania Spinosa (Argan) Kernel Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Borago Officinalis (Borage) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Oenothera Biennis (Evening Primrose) Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Echium Plantagineum Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Ceramide NS (hydration/skin replenishing), Cholesterol (hydration/skin replenishing)

  1. National Center for Biotechnology Information. "Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems"

    Accessed Jul. 30, 2021.
  2. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Jul. 30, 2021.

10. Granactive Retinoid 2% Emulsion

The Ordinary Granactive Retinoid 2% Emulsion

The Ordinary Serum for Anti-Aging

The Ordinary Granactive Retinoid 2% Emulsion

This is a cult-favorite The Ordinary product, and one of the best for preventing and reducing the appearance of fine lines and wrinkles without the irritation often associated with traditional retinol.

Skin types: All Skin Types
Best for: Anti-Aging
Tested on animals: No
How to use: At night, after cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
See on Amazon

The unique, next-generation retinoid actives in this serum makes it one of the best The Ordinary products for those who want to use a retinol but are worried about irritation. Retinoids (vitamin A derivatives) are well-known for preventing and reducing the appearance of fine lines, wrinkles, and other signs of aging.

Pros

  • Oil-free
  • Alcohol-free
  • Fragrance-free
  • Lightweight
  • Vegan and cruelty-free

Cons

  • Those with retinoid experience may prefer a stronger product

This product contains granactive retinoid, a complex of solubilized hydroxypinacolone retinoate (HPR). This form of retinoid offers anti-aging benefits without the irritation associated with retinol (which is also a vitamin A derivative). It also contains retinol that comes in a protective capsule to further prevent irritation, boost anti-aging benefits, and support the granactive retinoid.

Aqua (Water), Glycerin, Caprylic/Capric Triglyceride, Ethyl Linoleate, Propanediol, Dimethyl Isosorbide, Cetearyl Isononanoate, Bisabolol, Hydroxypinacolone Retinoate, Retinol, Tasmannia Lanceolata Fruit/Leaf Extract, Inulin Lauryl Carbamate, Glyceryl Stearate, Ceteareth-12, Ceteareth-20, Cetearyl Alcohol, Carrageenan, Xanthan Gum, Acacia Senegal Gum, Cetyl Palmitate, Sucrose Laurate, Polysorbate 20, Isoceteth-20, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, Behentrimonium Chloride, Trisodium Ethylenediamine Disuccinate, Disodium EDTA, Dehydroacetic Acid, Benzoic Acid, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Aug. 11, 2021.

11. Retinol 1% in Squalane

The Ordinary Retinol 1% in Squalane

The Ordinary Serum for Fighting the Signs of Aging

The Ordinary Retinol 1% in Squalane

This product is the highest-strength retinoid serum from The Ordinary, and the brand’s answer to more traditional retinol products. It’s excellent for preventing and minimizing the signs of aging.

Skin types: All Skin Types
Best for: Fighting the Signs of Aging
Tested on animals: No
How to use: At night, after cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
See on Amazon

Retinol is the gold-standard for minimizing wrinkles, fine lines, and hyperpigmentation. Those who are experienced with retinoid products may prefer the Retinol 1% in Squalane over the Granactive Retinoid 2% Emulsion, as it is more potent. However, with the higher strength comes a higher risk of irritation, so it is best suited for those who’ve used retinoid products in their routine.

Pros

  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • High likelihood of irritation, especially as skin adapts to the product

This serum contains squalane and jojoba oil, two ingredients that hydrate and soothe the skin. They may help minimize the irritation caused by the retinol.

Squalane, Caprylic/Capric Triglyceride, Simmondsia Chinensis (Jojoba) Seed Oil, Retinol, Solanum Lycopersicum (Tomato) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, BHT.

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Aug. 11, 2021.

12. Buffet Serum

The Ordinary Buffet

The Ordinary Serum for Fighting the Signs of Aging

The Ordinary “Buffet”

“Buffet” is a multi-purpose serum that combines a variety of peptide complexes, amino acids, and hyaluronic acids to address signs of aging.

Skin types: All Skin Types
Best for: Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
See on Amazon

Peptides are excellent for reducing wrinkles, improving the skin’s barrier, and promoting skin elasticity. This gel-like serum from The Ordinary pulls out all the stops with six peptide complexes for potent anti-aging benefits.

Pros

  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

In addition to the peptide complexes, this serum contains 11 amino acids that help increase the skin’s hydration and further fight the signs of aging. It also contains multiple hyaluronic acid complexes, which attract moisture to the skin and reduce the appearance of fine lines.

Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

13. Anti-Aging Pore Minimizer Face Serum

La Roche-Posay Effaclar Anti-Aging Pore Minimizer Face Serum

La Roche-Posay Serum for Minimizing Pores and Exfoliating

La Roche-Posay Effaclar Anti-Aging Pore Minimizer Face Serum

This serum is packed with chemical exfoliators and additional ingredients that help minimize the appearance of pores, while also smoothing the skin’s texture and reducing fine lines.

Skin types: Normal, Oily and Combination
Best for: Minimizing Pores and Exfoliating
Tested on animals: No
How to use: After cleansing, apply two to three drops to the face. Follow up with a moisturizer.
See on Amazon

This serum is excellent for both minimizing the appearance of enlarged pores and reducing fine lines. Lipo-hydroxy acid (which is a derivative of salicylic acid) helps diminish the appearance of enlarged pores, while also brightening and evening tone and texture. Glycolic acid works on the surface of the skin to smooth texture and minimize lines.

Pros

  • Fragrance-free
  • Non-comedogenic
  • Dermatologist tested

Cons

  • May irritate more sensitive skin

In addition to the chemical exfoliators mentioned above, this serum contains hyaluronic acid, which keeps the skin hydrated and helps counteract the potentially drying effects of the exfoliators.

Water, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycolic Acid, Diisopopyl Adipate, Propylene Glycol, Pentylene Glycol, Citric Acid, Ppg-26-buteth-26, Peg-30 Glyceryl Cocoate, Peg-40 Hydrogenated Castor Oil, Sodium Hydroxide, P-anisic Acid, Hydrolyzed Hyaluronic Acid, Capryloyl Salicylic Acid, Tetrasodium Edta, Polyquaternium-10.

  1. National Center for Biotechnology Information. "The Use of Lipohydroxy Acid in Skin Care and Acne Treatment"

    Accessed Aug. 16, 2021.
  2. National Center for Biotechnology Information. "An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin"

    Accessed Aug. 16, 2021.

14. 10% Pure Vitamin C Serum

La Roche-Posay 10% Pure Vitamin C Serum

La Roche-Posay Serum for Hyperpigmentation and Wrinkles

La Roche-Posay 10% Pure Vitamin C Serum

This serum contains a potent concentration of vitamin C, which is known for its ability to brighten, diminish post-inflammatory hyperpigmentation, and even skin tone.

Skin types: All Skin Types
Best for: Hyperpigmentation and Wrinkles
Tested on animals: Yes
How to use: After cleansing, apply the serum all over the face, neck, and chest.
See on Amazon

Vitamin C is an incredibly effective skincare ingredient that is known to boost collagen production, which in turn brightens, fades hyperpigmentation, and diminishes fine lines and wrinkles. This serum contains a potent 10% concentration of vitamin C (ascorbic acid), which will help even overall skin tone and texture.

Pros

  • Oil-free
  • Dermatologist tested

Cons

  • Contains fragrance

In addition to ascorbic acid, this serum contains salicylic acid, which gently exfoliates, and hyaluronic acid and sodium hyaluronate, which draw moisture to the skin.

Aqua/Water/Eau, Ascorbic Acid, Cyclohexasiloxane, Glycerin, Alcohol Denat., Potassium Hydroxide, Polymethylsilsesquioxane, Polysilicone-11, Dimethicone, Propylene Glycol, Pentaerythrityl Tetraethylhexanoate, C13-14 Isoparaffin, Tocopherol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Adenosine, Acetyl Dipeptide-1 Cetyl Ester, Peg-20 Methyl Glucose Sesquistearate, Poloxamer 338, Salicylic Acid, Polyacrylamide, Toluene Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Bht, Laureth-7, Parfum/Fragrance.

  1. National Center for Biotechnology Information. "The Roles of Vitamin C in Skin Health"

    Accessed Aug. 16, 2021.

15. Antioxidant Serum with SPF 50 Sunscreen

La Roche-Posay Anthelios AOX Antioxidant Serum with SPF 50 Sunscreen

La Roche-Posay Serum for Daily Sun Protection

La Roche-Posay Anthelios AOX Antioxidant Serum with SPF 50 Sunscreen

This product not only provides SPF protection to defend against UVA and UVB rays, but it also contains antioxidants to defend against free radicals that accelerate aging.

Skin types: Normal, Oily, Dry and Combination
Best for: Daily Sun Protection
Tested on animals: Yes
How to use: During the day, after applying serums and a moisturizer, apply the sunscreen to your face, neck, and chest. Reapply every two hours.
See on Amazon

Prevention is key when it comes to maintaining youthful skin, and this water-based serum sunscreen is an excellent choice. The SPF 50 protects the skin from the sun’s rays, which can contribute to premature aging. Additionally, the antioxidant blend protects against damaging free radicals that these UV rays cause.

Pros

  • Fragrance-free
  • Oil-free
  • Dermatologist tested

Cons

  • Not water resistant (use a water resistant sunscreen when swimming or sweating)
  • Contains chemical sunscreen, which may irritate sensitive skin

The antioxidant blend in this sunscreen includes vitamin E, vitamin C, baicalin, and senna alata.

Active: Avobenzone 2.68% (sunscreen), Homosalate 9.60% (sunscreen), Octisalate 2.88% (sunscreen), Octocrylene 5.38% (sunscreen), Oxybenzone 3.46% (sunscreen). Inactive: Water, Dimethicone, Cyclopentasiloxane, Tocopherol, Acrylates/Dimethicone Copolymer, Phenoxyethanol, Propylene Glycol, Caprylyl Glycol, Silica, Sodium Polyacrylate, Ascorbyl Glucoside, Scutellaria Baicalensis Root Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Diethylhexyl Syringylidenemalonate, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Cassia Alata Leaf Extract, Maltodextrin, Triethanolamine.

  1. American Academy of Dermatology. "Is Sunscreen Safe?"

    Accessed Aug. 20, 2021.

16. Vitamin C Suspension 23% + HA Spheres 2%

The Ordinary Vitamin C Suspension 23% + HA Spheres 2%

The Ordinary Serum for Evening Skin Tone and Fighting the Signs of Aging

The Ordinary Vitamin C Suspension 23% + HA Spheres 2%

This is one of the best The Ordinary products to add to your skincare routine, because it contains a potent concentration of vitamin C (ascorbic acid), which brightens and evens out overall skin tone while fighting the signs of aging.

Skin types: All Skin Types
Best for: Evening Skin Tone and Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Those looking to brighten their skin tone while also fighting against the signs of aging should turn to this product, which has the highest concentration of antioxidant-rich vitamin C of any of the products the brand offers. Since vitamin C has been shown to help with hyperpigmentation, this option is also great for those looking to even out dark spots. In addition to vitamin C, this product contains sodium hyaluronate (the sodium salt of hyaluronic acid), which increases moisture in the skin.

Pros

  • Oil-free
  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

Since this product contains such a high percentage of vitamin C, some users may experience tingling as their skin adjusts, particularly if they’re newer to topical vitamin C.

Ascorbic Acid, Squalane, Isodecyl Neopentanoate, Isononyl Isononanoate, Coconut Alkanes, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Sodium Hyaluronate, Glucomannan, Coco-Caprylate/Caprate, Butylene/Ethylene/Styrene Copolymer, Acrylates/Ethylhexyl Acrylate Crosspolymer, Trihydroxystearin, BHT.

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Aug. 11, 2021.

17. 1% Retinol Treatment

Paula’s Choice Clinical 1% Retinol Treatment

Paula's Choice Serum for Hyperpigmentation and Wrinkles

Paula’s Choice Clinical 1% Retinol Treatment

This treatment combines retinol, a powerful anti-aging ingredient, with hydrating and brightening ingredients for an even, smooth skin tone.

Skin types: All Skin Types
Best for: Hyperpigmentation and Wrinkles
Tested on animals: No
How to use: After cleansing, massage a pea-sized amount of the treatment into the skin. Initially, limit usage to three times a week to allow the skin to adjust.
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Retinol is the gold-standard for fighting signs of aging, so this is an excellent choice for those with wrinkles, fine lines, and sun spots. The addition of soothing and hydrating ingredients helps counteract some of the potential irritating side effects of retinol.

Pros

  • Fragrance-free
  • Lightweight
  • Non-greasy

Cons

  • May irritate more sensitive skin types

This serum contains vitamin C, which brightens the skin, as well as licorice extract and oat extract, which soothe and calm redness.

Water (Aqua), Dimethicone (skin-softening), Glycerin (skin-replenishing), Butylene Glycol (hydrating), Isononyl Isononanoate (emollient), Castor Isostearate Succinate (skin-softening ), Glyceryl Stearate (texture enhancer), C12-15 Alkyl Benzoate (emollient), Dimethicone Crosspolymer (texture enhancer), PEG-33 (stabilizer), Polysorbate 20 (texture enhancer), Behenyl Alcohol (texture enhancer), PEG-100 Stearate (texture enhancer), Pentaerythrityl Tetraisostearate (stabilizer), Polymethylsilsesquioxane (texture enhancer), Tetrahexyldecyl Ascorbate (vitamin C/antioxidant), Retinol (skin-restoring), Ceramide NG (skin-replenishing) , Palmitoyl Tetrapeptide-7 (skin-restoring), Palmitoyl Hexapeptide-12 (skin-restoring), Sodium Hyaluronate (skin-replenishing ), Dipotassium Glycyrrhizate (antioxidant plant extracts/skin-soothing), Glycyrrhiza Glabra Root Extract (licorice extract/antioxidant/skin-soothing), Avena Sativa Kernel Extract (oat extract/antioxidant/skin-soothing), Arctium Lappa Root Extract (burdock extract/antioxidant/skin-soothing), Salix Alba Bark Extract (willow bark extract/antioxidant/skin-soothing), Glycine Soja Sterols (antioxidant/skin-softening ), Lecithin (skin-restoring), Allantoin (skin-soothing), Tocopheryl Acetate (vitamin E/antioxidant), Hydrolyzed Soy Protein (antioxidant/skin-softening), Sorbitan Laurate (texture enhancer), Acetyl Dipeptide-1 Cetyl Ester (skin-soothing), Disodium EDTA (stabilizer), Hydroxyethylcellulose (texture enhancer), Palmitoyl Tripeptide-1 (skin-restoring), Sodium Hydroxide (pH adjuster), Tribehenin (emollient), Caprylyl Glycol (skin-softening), Ethylhexylglycerin (skin-softening), Pentylene Glycol (hydrating), PEG-75 Shea Butter Glycerides (emollient), PPG-12/SMDI Copolymer (stabilizer), PEG-10 Phytosterol (fatty acid-based emollient), PEG-8 Dimethicone (skin-softening), PEG-14 (texture enhancer), Magnesium Aluminum Silicate (texture enhancer), Arachidyl Glucoside (texture enhancer), Arachidyl Alcohol (texture enhancer), Sclerotium Gum (texture enhancer), Carbomer (gel-based texture enhancer), Phenoxyethanol (preservative), Benzoic Acid (preservative)

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Jul. 30, 2021.

18. 20% Vitamin C + E Ferulic Acid Serum

Timeless 20% Vitamin C + E Ferulic Acid Serum

Timeless Serum for Brightening and Anti-Aging

Timeless 20% Vitamin C + E Ferulic Acid Serum

This affordable vitamin C serum contains a 20% concentration of vitamin C, which helps brighten and fight signs of aging.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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This lightweight serum contains a 20% concentration of l-ascorbic acid, a form of vitamin C that works to brighten and provide anti-aging benefits. It also contains vitamin E and ferulic acid, two skincare ingredients that protect the skin from environmental stressors and have also been shown to increase the efficacy of vitamin C.

Pros

  • Lightweight
  • Affordable
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some reviewers complain about the pump

In addition to the ingredients mentioned above, this serum contains hyaluronic acid, which attracts moisture to the skin to keep it hydrated.

Water, Ethoxydiglycol, L-Ascorbic Acid, Propylene Glycol, Alpha Tocopherol, Polysorbate 80, Panthenol, Ferulic Acid, Sodium Hyaluronate, Benzylalcohol, Dehydroacetic Acid

  1. National Center for Biotechnology Information. "Vitamin C in Dermatology"

    Accessed Aug. 31, 2021.

19. Vitamin C Serum

TruSkin Vitamin C Serum

TruSkin Serum for Brightening and Anti-Aging

TruSkin Vitamin C Serum

This gentle and affordable serum contains vitamin C, which brightens and fights signs of aging, as well as other soothing and hydrating skincare ingredients.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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This vitamin C serum contains sodium ascorbyl phosphate, a stable form of vitamin C that helps brighten and provide anti-aging benefits. It also contains hyaluronic acid, which attracts moisture to the skin, and vitamin E, an antioxidant that protects against free radical damage to the skin.

Pros

  • Affordable
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • Some acne-prone reviewers noted that it broke them out

In addition to the ingredients mentioned above, this serum contains jojoba oil, which moisturizes, and witch hazel, which soothes.

Organic Deionized Herbal Infusion, Organic Aloe Barbadensis Leaf (Aloe), Sodium Ascorbyl Phosphate (Vitamin C), MSM, Botanical Hyaluronic Acid (Cassia Angustifolia Seed Polysaccharide), Hamamelis Virginiana (Witch Hazel), Vitamin E (d-alpha Tocopheryl Acetate), Carbomer, (2s)-2-Amino-5-guanidinopentanoic Acid, Organic Gotu Kola, Wildcrafted Horsetail (Equisetum Arvense), Wildcrafted Dandelion, Wildcrafted Geranium, Organic Jojoba Oil (Organic Simmondsia Chinensis), Phenoxyethanol, Ethyl Hexyl Glycerin.

  1. National Center for Biotechnology Information. "Sodium ascorbyl phosphate in topical microemulsions"

    Accessed Aug. 31, 2021.
  2. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Aug. 31, 2021.

20. Vitamin C Concentrated Serum

Derma E Vitamin C Concentrated Serum

Derma E Serum for Brightening and Anti-Aging

Derma E Vitamin C Concentrated Serum

This affordable vitamin C serum contains a stable and effective form of vitamin C, as well as additional ingredients that help hydrate and soothe the skin.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
See on Amazon

Vitamin C – an antioxidant that fights free radicals that can damage the skin – is key for a rounded out skincare routine, and this option is affordable and effective. It contains sodium ascorbyl phosphate, a stable form of vitamin C that doesn’t deteriorate as easily as other forms. It is able to brighten the skin and fight signs of aging, including fine lines, wrinkles, and dark spots.

Pros

  • Affordable
  • Lightweight
  • Vegan and cruelty-free

Cons

  • Contains fragrance

In addition to vitamin C, this serum contains a blend of ingredients that hydrate, soothe, and nourish the skin, including hyaluronic acid, green tea leaf extract, rosehip oil, and aloe vera extract.

Purified Water, Glycerin (Vegetable Derived), Sodium Ascorbyl Phosphate (Vitamin C, Stay-C 50), Sodium Hyaluronate (Hyaluronic Acid), Organic Camellia Sinensis (Green Tea) Leaf Extract*, Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Alpha-Glucan Oligosaccharide (Vegetable Derived), Polymnia Sonchifolia (Yacon) Root Juice, Maltodextrin, Lactobacillus (Probiotic), Rosa Canina (Rosehip) Fruit Oil, Organic Aloe Barbadensis (Aloe Vera) Extract *, Allantoin, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Caprylic/Capric Triglyceride (Plant Derived), Ethylhexyl Palmitate, Xanthan Gum, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils

  1. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Aug. 31, 2021.
  2. National Center for Biotechnology Information. "Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies"

    Accessed Aug. 31, 2021.
  3. National Center for Biotechnology Information. "Sodium ascorbyl phosphate in topical microemulsions"

    Accessed Aug. 31, 2021.

21. C15 Super Booster

Paula's Choice C15 Super Booster

Paula's Choice Serum for Brightening and Fighting Signs of Aging

Paula's Choice C15 Super Booster

The 15% concentration of pure vitamin C in this serum helps brighten the skin while reducing the appearance of fine lines and wrinkles.

Skin types: All Skin Types
Best for: Brightening and Fighting Signs of Aging
Tested on animals: No
How to use: Massage two to three drops of the serum into clean skin. Follow up with a moisturizer.
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This lightweight serum is one of the best Paula’s Choice products, as it contains a powerful concentration of vitamin C, which evens out and brightens the skin tone while also minimizing fine lines and wrinkles. It also contains ingredients that hydrate and soothe the skin.

Pros

  • Fragrance-free
  • Lightweight
  • Non-greasy

Cons

  • May irritate more sensitive skin types

In addition to vitamin C, this serum contains ferulic acid and vitamin E. These antioxidants protect the skin, and are also known to increase the efficacy of vitamin C.

Water (Aqua), Ascorbic Acid (vitamin C/antioxidant), Butylene Glycol (solvent/texture enhancer), Ethoxydiglycol (solvent/texture enhancer), Glycerin (skin-replenishing), PPG-26-Buteth-26 (emulsifier/skin-softening), PEG-40 Hydrogenated Castor Oil (emulsifier/solubility enhancer), Pentylene Glycol (skin-softening slip agent), Tocopherol (vitamin E/stabilizing antioxidant), Sodium Hyaluronate (hydration), Hexanoyl Dipeptide-3 Norleucine Acetate (skin-restoring peptide), Lecithin (skin-restoring/hydration), Ferulic Acid (stabilizing antioxidant), Panthenol (vitamin B5/skin-softening, skin-soothing), Bisabolol (skin-soothing), Oryza Sativa (Rice) Bran Extract (skin-softening/chelating agent), Propyl Gallate (antioxidant), Sodium Gluconate (chelating agent), Sodium Hydroxide (pH adjuster), Phenoxyethanol (preservative), Ethylhexylglycerin (preservative)

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Jul. 30, 2021.

22. C-Firma Vitamin C Day Serum

Drunk Elephant C-Firma Vitamin C Day Serum

Drunk Elephant Serum for Fading Hyperpigmentation and Anti-Aging

Drunk Elephant C-Firma Vitamin C Day Serum

This serum contains a potent concentration of vitamin C, which is excellent for brightening and lightening post-inflammatory hyperpigmentation, as well as fighting the signs of aging.

Skin types: All Skin Types
Best for: Fading Hyperpigmentation and Anti-Aging
Tested on animals: No
How to use: Massage the serum into the face, neck, and chest. Follow up with a moisturizer, as well as SPF during the day.
See on Amazon

This serum contains a 15% concentration of vitamin C (l-ascorbic acid), which promotes the production of collagen. This in turn helps minimize the appearance of hyperpigmentation, while also providing anti-aging benefits. It also contains antioxidant-rich ferulic acid and vitamin E, which protect the skin from environmental stressors, and have also been shown to increase the efficacy of vitamin C.

Pros

  • Fragrance-free
  • Lightweight
  • Cruelty-free

Cons

  • Some reviewers complain about the smell

In addition to the blend of vitamin C, vitamin E, and ferulic acid, this serum contains pumpkin ferment and pomegranate extract, which dissolve skin cells on the surface of the skin for even, smooth skin.

Water/Aqua/Eau, Dimethyl Isosorbide, Ascorbic Acid, Laureth-23, Glycerin, Lactobacillus/Pumpkin Ferment Extract, Sclerocarya Birrea Seed Oil, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra (Licorice) Root Extract, Vitis Vinifera (Grape) Juice Extract, Phyllanthus Emblica Fruit Extract, Camellia Sinensis Leaf Extract, Tocopherol, Lactobacillus/Punica Granatum Fruit Ferment Extract, Sodium Hyaluronate Crosspolymer, Hydrolyzed Quinoa, Phytosterols, Glutamylamidoethyl Imidazole, Hydrolyzed Wheat Protein, Ferulic Acid, Acetyl Glucosamine, Sodium Hyaluronate, Tetrahydrobisdemethoxydiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrodiferuloylmethane, Glycine, Leuconostoc/Radish Root Ferment Filtrate, Sucrose, Maltodextrin, Chondrus Crispus Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Phenoxyethanol, Caprylhydroxamic Acid, Caprylyl Glycol, Sorbitan Isostearate, Propanediol, Pentylene Glycol, Xanthan Gum, Butylene Glycol, Sodium Hydroxide, Chlorphenesin, Polysorbate 60, Sodium Dehydroacetate, Potassium Sorbate, Sorbic Acid, Ethylhexylglycerin

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Jul. 30, 2021.

FAQs

What is the best serum for deep wrinkles?

If you’re dealing with deep wrinkles, you may want to look into adding a retinol to your skincare routine, in addition to one (or a few) of the serums mentioned above. You may also want to talk to a dermatologist about deep wrinkle treatments (such peels, dermabrasion, and laser treatments) that can be done in a medical setting. Adding anti-aging ingredients like vitamin C, AHAs, and peptides to your routine can certainly help minimize the appearance of lines, but deeper wrinkles may also require a retinol product and/or a professional treatment for the best results.

Which is better for wrinkles: retinol or hyaluronic acid?

Hyaluronic acid pulls moisture to the skin to keep it hydrated, and it has been shown to help soften the appearance of fine lines and wrinkles. However, retinol is the gold standard for anti-aging, and is the more effective ingredient when it comes to fighting wrinkles. That said, both of these skincare ingredients can be used in your routine for maximum anti-aging results. Hyaluronic acid and retinol products can also be layered together.

Can you reverse deep wrinkles?

With the right treatment, deep wrinkles can be reversed. Retinol, vitamin C, AHAs, and peptides are all great ingredients to use in an anti-aging skincare routine, and can help smooth the appearance of wrinkles. However, if you’re looking to reverse deep wrinkles, you may need a treatment from a medical professional.

The Bottom Line

If you want to soften lines and prevent new ones from forming, these are some of the best serums for wrinkles. Consider adding some of these products to your medicine cabinet for a well-rounded anti-aging skincare routine.