Retinol is one of the absolute best ingredients to use if you’re looking to smooth fine lines and wrinkles while also preventing new lines from forming. If you want to add this gold-standard ingredient to your anti-aging skincare routine, here is our guide to the best retinols for wrinkles.

Our Recommendations

1. Rapid Wrinkle Repair Regenerating Cream

Rapid Wrinkle Repair Regenerating Cream

Neutrogena Retinol for Moisturization and Anti-Aging

Neutrogena Rapid Wrinkle Repair Regenerating Cream

This cream moisturizer combines the power of retinol and hyaluronic acid to fight the signs of aging while also plumping and moisturizing the skin.

Skin types: Normal, Dry and Combination
Best for: Moisturization and Anti-Aging
Tested on animals: Yes
How to use: After cleansing, apply the cream to your face, neck, and chest.
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This anti-aging moisturizer is a great way to add retinol to your routine, as the addition of moisturizing ingredients may help mitigate some of the irritation often associated with retinol. The cream contains retinol SA, which works to smooth lines and even skin tone. It also contains hyaluronic acid, which pulls moisture to the skin for healthy hydration levels.

Pros

  • Anti-aging
  • Fragrance-free
  • Non-greasy
  • Hydrating

Cons

  • May cause irritation

In addition to the hydrating benefits, hyaluronic acid has been shown to help minimize the appearance of fine lines and wrinkles, which makes this drugstore moisturizer even more effective for anti-aging. Even though the hydrating ingredients may mitigate the irritating effects of retinol, if you’re new to this skincare ingredient or have sensitive skin, you may want to start by using this cream every other day or every two days to see how your skin reacts.

Water, Pentaerythrityl Tetraethylhexanoate, Glycerin, Dimethicone, PPG 15 Stearyl Ether, Stearyl Alcohol, Cetearyl Alcohol, Butylene Glycol, Glyceryl Behenate, Ceteareth 20, Isohexadecane, Dimethicone Crosspolymer, Cyclopentasiloxane, Polyethylene, Sodium Polyacrylate, Phenoxyethanol, Caprylyl Glycol, Sodium Acryloyldimethyltaurate/VP Crosspolymer, Polyacrylamide, PTFE, C13-14 Isoparaf n, Chlorphenesin, Polysorbate 20, Hydrolyzed Myrtus Communis Leaf Extract, Retinol, BHT, Sodium Hyaluronate, Disodium EDTA, Sodium Hydroxide, Laureth-7, Ascorbic Acid

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Nov. 8, 2021.
  2. National Center for Biotechnology Information. "Hyaluronic acid: A key molecule in skin aging"

    Accessed Nov. 8, 2021.

2. Resurfacing Retinol Serum

CeraVe Resurfacing Retinol Serum

CeraVe Retinol for Fading post-inflammatory hyperpigmentation and minimizing large pores

CeraVe Resurfacing Retinol Serum

This drugstore retinol serum is specifically formulated to tackle post-inflammatory hyperpigmentation and large pores, and helps promote an overall even and clear complexion.

Skin types: Normal, Oily and Combination
Best for: Fading post-inflammatory hyperpigmentation and minimizing large pores
Tested on animals: Yes
How to use: After cleansing, apply a pump of the serum evenly all over the face, neck, and chest. Use once a day (or less frequently to prevent irritation).
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This is an excellent choice for those looking for an affordable retinol. This fragrance-free retinol serum not only helps with acne scars and large pores, but it can also help fight signs of aging and brighten the skin.

Pros

  • Affordable
  • Lightweight
  • Non-comedogenic
  • Fragrance-free
  • Developed with dermatologists

Cons

  • May cause irritation or dryness

This non-comedogenic retinol serum also contains ceramides and niacinamide, which work to calm and restore the skin while maintaining its barrier. Additionally, this formula contains licorice root extract, which gives a brightening boost. That extra benefit may further help lighten discolored scars.

Aqua/Water, Propanediol, Dimethicone, Cetearyl Ethylhexanoate, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Dipotassium Glycyrrhizate, Hydrogenated Lecithin, Potassium Phosphate, Ceramide Np, Ceramide Ap, Ceramide Eop, Carbomer, Cetearyl Alcohol, Behentrimonium Methosulfate, Dimethiconol, Lecithin, Sodium Citrate, Retinol, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Cholesterol, Phenoxyethanol, Alcohol, Isopropyl Myristate, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Pentylene Glycol, Phytosphingosine, Xanthan Gum, Polysorbate 20, Ethylhexylglycerin

  1. National Center for Biotechnology Information. "Why Topical Retinoids Are Mainstay of Therapy for Acne"

    Accessed Nov. 8, 2021.
  2. National Center for Biotechnology Information. "How Much Do We Really Know About Our Favorite Cosmeceutical Ingredients?"

    Accessed Nov. 8, 2021.
  3. National Center for Biotechnology Information. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products"

    Accessed Nov. 8, 2021.

3. RetrinAL 0.1 Intensive Cream

Avene_RetrinAL_0.1_Intensive_Cream

Avène Retinol for Fighting the Signs of Aging

Avène RetrinAL 0.1 Intensive Cream

This over-the-counter anti-aging retinol contains retinaldehyde, a potent retinoid, as well as other ingredients that help minimize the appearance of wrinkles, plump the skin, and protect against free radicals for a youthful complexion.

Skin types: Normal, Oily, Dry and Combination
Best for: Fighting the Signs of Aging
Tested on animals: Yes
How to use: At night, after cleansing and drying the skin, apply to the face, neck, and chest. Follow up with a moisturizer.
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The star ingredient of this over-the-counter, fragrance-free retinol treatment is retinaldehyde. This kind of retinoid is one of the strongest that you can get without a prescription, and it has been proven to stimulate collagen production, smooth the appearance of wrinkles, and brighten skin tone. It also contains peptides that help plump the skin.

Pros

  • Anti-aging
  • Fragrance-free
  • Formulated to minimize the risk of allergic reactions

Cons

  • Contains color additives
  • May cause irritation (especially for those new to using retinoids)

In addition to the peptides and retinaldehyde, this anti-aging treatment cream contains vitamin E, an antioxidant, as well as Avène thermal spring water, which is meant to soothe and soften the skin.

Water (Avène Thermal Spring Water), Triethylhexanoin, Cyclopentasiloxane, Cetearyl Alcohol, Cyclohexasiloxane, Ceteareth-20, Polymethyl Methacrylate, Ceteareth-33, Caprylic/Capric Triglyceride, Ammonium Acryloyl Dimethyltaurate/Vp Copolymer, Benzoic Acid, Bht, Caramel, Disodium Edta, Mica, Oenothera Biennis (Evening Primrose) Oil, Oleoyl Dipeptide-15, Oleoyl Tetrapeptide-31, Phenoxyethanol, Red 33, Retinal, Silica, Sodium Hydroxide, Titanium Dioxide, Tocopherol, Tocopheryl Glucoside

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety"

    Accessed Nov. 8, 2021.
  2. National Center for Biotechnology Information. "Vitamin E in dermatology"

    Accessed Nov. 8, 2021.

4. Granactive Retinoid 2% Emulsion

Granactive Retinoid 2% Emulsion

The Ordinary Retinol for Anti-Aging

The Ordinary Granactive Retinoid 2% Emulsion

This is a cult-favorite The Ordinary product, and one of the best for preventing and reducing the appearance of fine lines and wrinkles without the irritation often associated with traditional retinol.

Skin types: All Skin Types
Best for: Anti-Aging
Tested on animals: No
How to use: At night, after cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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The unique, next-generation retinoid actives in this serum makes it one of the best The Ordinary products for those who want to use a retinol but are worried about irritation. Retinoids (vitamin A derivatives) are well-known for preventing and reducing the appearance of fine lines, wrinkles, and other signs of aging.

Pros

  • Oil-free
  • Alcohol-free
  • Fragrance-free
  • Lightweight
  • Vegan and cruelty-free

Cons

  • Those with retinoid experience may prefer a stronger product

This product contains granactive retinoid, a complex of solubilized hydroxypinacolone retinoate (HPR). This form of retinoid offers anti-aging benefits without the irritation associated with retinol (which is also a vitamin A derivative). It also contains retinol that comes in a protective capsule to further prevent irritation, boost anti-aging benefits, and support the granactive retinoid.

Aqua (Water), Glycerin, Caprylic/Capric Triglyceride, Ethyl Linoleate, Propanediol, Dimethyl Isosorbide, Cetearyl Isononanoate, Bisabolol, Hydroxypinacolone Retinoate, Retinol, Tasmannia Lanceolata Fruit/Leaf Extract, Inulin Lauryl Carbamate, Glyceryl Stearate, Ceteareth-12, Ceteareth-20, Cetearyl Alcohol, Carrageenan, Xanthan Gum, Acacia Senegal Gum, Cetyl Palmitate, Sucrose Laurate, Polysorbate 20, Isoceteth-20, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, Behentrimonium Chloride, Trisodium Ethylenediamine Disuccinate, Disodium EDTA, Dehydroacetic Acid, Benzoic Acid, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Aug. 11, 2021.

5. Retinol 1% in Squalane

Retinol 1% in Squalane

The Ordinary Retinol for Fighting the Signs of Aging

The Ordinary Retinol 1% in Squalane

This product is the highest-strength retinoid serum from The Ordinary, and the brand’s answer to more traditional retinol products. It’s excellent for preventing and minimizing the signs of aging.

Skin types: All Skin Types
Best for: Fighting the Signs of Aging
Tested on animals: No
How to use: At night, after cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Retinol is the gold-standard for minimizing wrinkles, fine lines, and hyperpigmentation. Those who are experienced with retinoid products may prefer the Retinol 1% in Squalane over the Granactive Retinoid 2% Emulsion, as it is more potent. However, with the higher strength comes a higher risk of irritation, so it is best suited for those who’ve used retinoid products in their routine.

Pros

  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • High likelihood of irritation, especially as skin adapts to the product

This serum contains squalane and jojoba oil, two ingredients that hydrate and soothe the skin. They may help minimize the irritation caused by the retinol.

Squalane, Caprylic/Capric Triglyceride, Simmondsia Chinensis (Jojoba) Seed Oil, Retinol, Solanum Lycopersicum (Tomato) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, BHT.

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Aug. 11, 2021.

6. Retinol B3 Pure Retinol Serum

La Roche-Posay Retinol B3 Pure Retinol Serum

La Roche-Posay Retinol for Anti-Aging

La Roche-Posay Retinol B3 Pure Retinol Serum

Retinol is one of the gold standards for fighting wrinkles and signs of aging, and this serum combines retinol with soothing and hydrating ingredients for glowing skin.

Skin types: All Skin Types
Best for: Anti-Aging
Tested on animals: Yes
How to use: At night, after cleansing, apply three to four drops of the serum to the face and neck.
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Retinol is an incredibly effective ingredient for diminishing wrinkles, fine lines, and sun spots. The addition of sodium hyaluronate and niacinamide make this a soothing, hydrating, and effective anti-aging product.

Pros

  • Oil-free
  • Dermatologist tested

Cons

  • Contains fragrance

This serum contains a gradual release retinol, which slowly acts on the skin for maximum efficacy and better tolerance.

Aqua /Water / Eau,Glycerin , Cyclohexasiloxane,Alcohol Denat.,Pentylene Glycol,Niacinamide,Dimethicone,Glycine Soja Oil / Soybean Oil,Ppg-6-Decyltetradeceth-30, Sodium Hyaluronate,Retinol,Adenosine, Ammoniumpolyacryloyldimethyltaurate,Caprylyl Glycol,Citric Acid,Trisodium Ethylenediamine Disuccinate,Xanthan Gum,Polysilicone-11, Retinyl Palmitate,Tocopherol,Phenoxyethanol, Parfum/ Fragrance.

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Aug. 16, 2021.

7. 1% Retinol Treatment

Paula’s Choice Clinical 1% Retinol Treatment

Paula's Choice Retinol for Hyperpigmentation and Wrinkles

Paula’s Choice Clinical 1% Retinol Treatment

This treatment combines retinol, a powerful anti-aging ingredient, with hydrating and brightening ingredients for an even, smooth skin tone.

Skin types: All Skin Types
Best for: Hyperpigmentation and Wrinkles
Tested on animals: No
How to use: After cleansing, massage a pea-sized amount of the treatment into the skin. Initially, limit usage to three times a week to allow the skin to adjust.
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Retinol is the gold-standard for fighting signs of aging, so this is an excellent choice for those with wrinkles, fine lines, and sun spots. The addition of soothing and hydrating ingredients helps counteract some of the potential irritating side effects of retinol.

Pros

  • Fragrance-free
  • Lightweight
  • Non-greasy

Cons

  • May irritate more sensitive skin types

This serum contains vitamin C, which brightens the skin, as well as licorice extract and oat extract, which soothe and calm redness.

Water (Aqua), Dimethicone (skin-softening), Glycerin (skin-replenishing), Butylene Glycol (hydrating), Isononyl Isononanoate (emollient), Castor Isostearate Succinate (skin-softening ), Glyceryl Stearate (texture enhancer), C12-15 Alkyl Benzoate (emollient), Dimethicone Crosspolymer (texture enhancer), PEG-33 (stabilizer), Polysorbate 20 (texture enhancer), Behenyl Alcohol (texture enhancer), PEG-100 Stearate (texture enhancer), Pentaerythrityl Tetraisostearate (stabilizer), Polymethylsilsesquioxane (texture enhancer), Tetrahexyldecyl Ascorbate (vitamin C/antioxidant), Retinol (skin-restoring), Ceramide NG (skin-replenishing) , Palmitoyl Tetrapeptide-7 (skin-restoring), Palmitoyl Hexapeptide-12 (skin-restoring), Sodium Hyaluronate (skin-replenishing ), Dipotassium Glycyrrhizate (antioxidant plant extracts/skin-soothing), Glycyrrhiza Glabra Root Extract (licorice extract/antioxidant/skin-soothing), Avena Sativa Kernel Extract (oat extract/antioxidant/skin-soothing), Arctium Lappa Root Extract (burdock extract/antioxidant/skin-soothing), Salix Alba Bark Extract (willow bark extract/antioxidant/skin-soothing), Glycine Soja Sterols (antioxidant/skin-softening ), Lecithin (skin-restoring), Allantoin (skin-soothing), Tocopheryl Acetate (vitamin E/antioxidant), Hydrolyzed Soy Protein (antioxidant/skin-softening), Sorbitan Laurate (texture enhancer), Acetyl Dipeptide-1 Cetyl Ester (skin-soothing), Disodium EDTA (stabilizer), Hydroxyethylcellulose (texture enhancer), Palmitoyl Tripeptide-1 (skin-restoring), Sodium Hydroxide (pH adjuster), Tribehenin (emollient), Caprylyl Glycol (skin-softening), Ethylhexylglycerin (skin-softening), Pentylene Glycol (hydrating), PEG-75 Shea Butter Glycerides (emollient), PPG-12/SMDI Copolymer (stabilizer), PEG-10 Phytosterol (fatty acid-based emollient), PEG-8 Dimethicone (skin-softening), PEG-14 (texture enhancer), Magnesium Aluminum Silicate (texture enhancer), Arachidyl Glucoside (texture enhancer), Arachidyl Alcohol (texture enhancer), Sclerotium Gum (texture enhancer), Carbomer (gel-based texture enhancer), Phenoxyethanol (preservative), Benzoic Acid (preservative)

  1. National Center for Biotechnology Information. "Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety"

    Accessed Jul. 30, 2021.

FAQs

What is the best retinol cream for wrinkles?

Moisturizing creams containing retinol are great for those looking to more gently introduce this ingredient to their skincare routine. This is because they are typically less potent and also contain moisturizing and soothing ingredients that counteract the potentially drying and irritating effects of retinol. They’re also excellent for those with dry skin. One of the best retinol creams for wrinkles is the Neutrogena Rapid Wrinkle Repair Regenerating Cream.

Can retinol reduce existing wrinkles?

Yes, in addition to helping prevent the formation of fine lines and wrinkles, consistent use of retinol can help reduce the appearance of existing wrinkles. This is because retinol promotes the production of collagen, a protein that is essential for maintaining a more youthful complexion.

What is better for wrinkles: retinol or hyaluronic acid?

Both retinol and hyaluronic acid are excellent skincare ingredients to include in an anti-aging skincare routine. However, retinol is far more effective at actually treating and preventing wrinkles, as well as minimizing other signs of aging. That said, hyaluronic acid – which attracts moisture to the skin and locks it in – has been shown to help reduce the appearance of lines. Both of these ingredients can be used together for an effective anti-aging skincare routine, and you’ll find hyaluronic acid in a few of the products recommended above.

The Bottom Line

If you want to fight wrinkles and other signs of aging, retinol is one of the absolute best skincare ingredients to add to your routine. Anyone looking to smooth out wrinkles should consider using one of our recommended retinol products.