If you’re looking to diminish the appearance of wrinkles, a targeted serum can help. These are some of the best drugstore serums for wrinkles.

Our Recommendations

1. Buffet Serum

The Ordinary Buffet

The Ordinary Serum for Fighting the Signs of Aging

The Ordinary “Buffet”

“Buffet” is a multi-purpose serum that combines a variety of peptide complexes, amino acids, and hyaluronic acids to address signs of aging.

Skin types: All Skin Types
Best for: Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Peptides are excellent for reducing wrinkles, improving the skin’s barrier, and promoting skin elasticity. This gel-like serum from The Ordinary pulls out all the stops with six peptide complexes for potent anti-aging benefits.

Pros

  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

In addition to the peptide complexes, this serum contains 11 amino acids that help increase the skin’s hydration and further fight the signs of aging. It also contains multiple hyaluronic acid complexes, which attract moisture to the skin and reduce the appearance of fine lines.

Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

2. 10% Pure Vitamin C Serum

La Roche-Posay 10% Pure Vitamin C Serum

La Roche-Posay Serum for Hyperpigmentation and Wrinkles

La Roche-Posay 10% Pure Vitamin C Serum

This serum contains a potent concentration of vitamin C, which is known for its ability to brighten, diminish post-inflammatory hyperpigmentation, and even skin tone.

Skin types: All Skin Types
Best for: Hyperpigmentation and Wrinkles
Tested on animals: Yes
How to use: After cleansing, apply the serum all over the face, neck, and chest.
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Vitamin C is an incredibly effective skincare ingredient that is known to boost collagen production, which in turn brightens, fades hyperpigmentation, and diminishes fine lines and wrinkles. This serum contains a potent 10% concentration of vitamin C (ascorbic acid), which will help even overall skin tone and texture.

Pros

  • Oil-free
  • Dermatologist tested

Cons

  • Contains fragrance

In addition to ascorbic acid, this serum contains salicylic acid, which gently exfoliates, and hyaluronic acid and sodium hyaluronate, which draw moisture to the skin.

Aqua/Water/Eau, Ascorbic Acid, Cyclohexasiloxane, Glycerin, Alcohol Denat., Potassium Hydroxide, Polymethylsilsesquioxane, Polysilicone-11, Dimethicone, Propylene Glycol, Pentaerythrityl Tetraethylhexanoate, C13-14 Isoparaffin, Tocopherol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Adenosine, Acetyl Dipeptide-1 Cetyl Ester, Peg-20 Methyl Glucose Sesquistearate, Poloxamer 338, Salicylic Acid, Polyacrylamide, Toluene Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Bht, Laureth-7, Parfum/Fragrance.

  1. National Center for Biotechnology Information. "The Roles of Vitamin C in Skin Health"

    Accessed Aug. 16, 2021.

3. Vitamin C Suspension 23% + HA Spheres 2%

The Ordinary Vitamin C Suspension 23% + HA Spheres 2%

The Ordinary Serum for Evening Skin Tone and Fighting the Signs of Aging

The Ordinary Vitamin C Suspension 23% + HA Spheres 2%

This is one of the best The Ordinary products to add to your skincare routine, because it contains a potent concentration of vitamin C (ascorbic acid), which brightens and evens out overall skin tone while fighting the signs of aging.

Skin types: All Skin Types
Best for: Evening Skin Tone and Fighting the Signs of Aging
Tested on animals: No
How to use: After cleansing, apply the product to the face, neck, and chest. Follow up with a moisturizer.
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Those looking to brighten their skin tone while also fighting against the signs of aging should turn to this product, which has the highest concentration of antioxidant-rich vitamin C of any of the products the brand offers. Since vitamin C has been shown to help with hyperpigmentation, this option is also great for those looking to even out dark spots. In addition to vitamin C, this product contains sodium hyaluronate (the sodium salt of hyaluronic acid), which increases moisture in the skin.

Pros

  • Oil-free
  • Alcohol-free
  • Fragrance-free
  • Vegan and cruelty-free

Cons

  • May irritate sensitive skin

Since this product contains such a high percentage of vitamin C, some users may experience tingling as their skin adjusts, particularly if they’re newer to topical vitamin C.

Ascorbic Acid, Squalane, Isodecyl Neopentanoate, Isononyl Isononanoate, Coconut Alkanes, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Sodium Hyaluronate, Glucomannan, Coco-Caprylate/Caprate, Butylene/Ethylene/Styrene Copolymer, Acrylates/Ethylhexyl Acrylate Crosspolymer, Trihydroxystearin, BHT.

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Aug. 11, 2021.

4. Vitamin C Concentrated Serum

Derma E Vitamin C Concentrated Serum

Derma E Serum for Brightening and Anti-Aging

Derma E Vitamin C Concentrated Serum

This affordable vitamin C serum contains a stable and effective form of vitamin C, as well as additional ingredients that help hydrate and soothe the skin.

Skin types: All Skin Types
Best for: Brightening and Anti-Aging
Tested on animals: No
How to use: After cleansing, apply the serum onto the face, neck, and chest. Follow up with a moisturizer, and an SPF during the day.
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Vitamin C – an antioxidant that fights free radicals that can damage the skin – is key for a rounded out skincare routine, and this option is affordable and effective. It contains sodium ascorbyl phosphate, a stable form of vitamin C that doesn’t deteriorate as easily as other forms. It is able to brighten the skin and fight signs of aging, including fine lines, wrinkles, and dark spots.

Pros

  • Affordable
  • Lightweight
  • Vegan and cruelty-free

Cons

  • Contains fragrance

In addition to vitamin C, this serum contains a blend of ingredients that hydrate, soothe, and nourish the skin, including hyaluronic acid, green tea leaf extract, rosehip oil, and aloe vera extract.

Purified Water, Glycerin (Vegetable Derived), Sodium Ascorbyl Phosphate (Vitamin C, Stay-C 50), Sodium Hyaluronate (Hyaluronic Acid), Organic Camellia Sinensis (Green Tea) Leaf Extract*, Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Alpha-Glucan Oligosaccharide (Vegetable Derived), Polymnia Sonchifolia (Yacon) Root Juice, Maltodextrin, Lactobacillus (Probiotic), Rosa Canina (Rosehip) Fruit Oil, Organic Aloe Barbadensis (Aloe Vera) Extract *, Allantoin, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Caprylic/Capric Triglyceride (Plant Derived), Ethylhexyl Palmitate, Xanthan Gum, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils

  1. National Center for Biotechnology Information. "Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils"

    Accessed Aug. 31, 2021.
  2. National Center for Biotechnology Information. "Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies"

    Accessed Aug. 31, 2021.
  3. National Center for Biotechnology Information. "Sodium ascorbyl phosphate in topical microemulsions"

    Accessed Aug. 31, 2021.

5. C15 Super Booster

Paula’s Choice C15 Super Booster

Paula's Choice Serum for Brightening and Fighting Signs of Aging

C15 Super Booster

The 15% concentration of pure vitamin C in this serum helps brighten the skin while reducing the appearance of fine lines and wrinkles.

Skin types: All Skin Types
Best for: Brightening and Fighting Signs of Aging
Tested on animals: No
How to use: Massage two to three drops of the serum into clean skin. Follow up with a moisturizer.
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This lightweight serum is one of the best Paula’s Choice products, as it contains a powerful concentration of vitamin C, which evens out and brightens the skin tone while also minimizing fine lines and wrinkles. It also contains ingredients that hydrate and soothe the skin.

Pros

  • Fragrance-free
  • Lightweight
  • Non-greasy

Cons

  • May irritate more sensitive skin types

In addition to vitamin C, this serum contains ferulic acid and vitamin E. These antioxidants protect the skin, and are also known to increase the efficacy of vitamin C.

Water (Aqua), Ascorbic Acid (vitamin C/antioxidant), Butylene Glycol (solvent/texture enhancer), Ethoxydiglycol (solvent/texture enhancer), Glycerin (skin-replenishing), PPG-26-Buteth-26 (emulsifier/skin-softening), PEG-40 Hydrogenated Castor Oil (emulsifier/solubility enhancer), Pentylene Glycol (skin-softening slip agent), Tocopherol (vitamin E/stabilizing antioxidant), Sodium Hyaluronate (hydration), Hexanoyl Dipeptide-3 Norleucine Acetate (skin-restoring peptide), Lecithin (skin-restoring/hydration), Ferulic Acid (stabilizing antioxidant), Panthenol (vitamin B5/skin-softening, skin-soothing), Bisabolol (skin-soothing), Oryza Sativa (Rice) Bran Extract (skin-softening/chelating agent), Propyl Gallate (antioxidant), Sodium Gluconate (chelating agent), Sodium Hydroxide (pH adjuster), Phenoxyethanol (preservative), Ethylhexylglycerin (preservative)

  1. National Center for Biotechnology Information. "Vitamin C in dermatology"

    Accessed Jul. 30, 2021.

FAQs

Which is better for wrinkles: retinol or hyaluronic acid?

Hyaluronic acid pulls moisture to the skin to keep it hydrated, and it has been shown to help soften the appearance of fine lines and wrinkles. However, retinol is the gold standard for anti-aging, and is the more effective ingredient when it comes to fighting wrinkles. That said, both of these skincare ingredients can be used in your routine for maximum anti-aging results. Hyaluronic acid and retinol products can also be layered together.

Can you reverse deep wrinkles?

With the right treatment, deep wrinkles can be reversed. Retinol, vitamin C, AHAs, and peptides are all great ingredients to use in an anti-aging skincare routine, and can help smooth the appearance of fine lines and wrinkles. However, if you’re looking to reverse deep wrinkles, you may need a treatment from a medical professional. Talk to a dermatologist about the best course of action for you.

How can I get rid of wrinkles on my face fast?

Topical products won’t be able to get rid of your wrinkles overnight. However, using the right products consistently can help diminish the appearance of fine lines and wrinkles over time. If you’re looking for faster results, a professional treatment (such as a chemical peel or laser treatment) may be the best option for you, if your dermatologist deems it appropriate for your needs. Preventative measures are also essential for slowing down the aging process. Wear sunscreen daily, and be sure to stay consistent with your anti-aging skincare routine.

The Bottom Line

Targeted serums can help diminish fine lines and wrinkles while also minimizing other signs of aging. Add one of the best drugstore serums for wrinkles to your skincare routine to help smooth lines.