13 Best Drugstore Serums for Wrinkles

This is an excellent choice for those looking for an affordable retinol. This fragrance-free retinol serum not only helps with acne scars and large pores, but it can also help fight signs of aging and brighten the skin.

This non-comedogenic retinol serum also contains ceramides and niacinamide, which work to calm and restore the skin while maintaining its barrier. Additionally, this formula contains licorice root extract, which gives a brightening boost. That extra benefit may further help lighten discolored scars.

Aqua/Water, Propanediol, Dimethicone, Cetearyl Ethylhexanoate, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Dipotassium Glycyrrhizate, Hydrogenated Lecithin, Potassium Phosphate, Ceramide Np, Ceramide Ap, Ceramide Eop, Carbomer, Cetearyl Alcohol, Behentrimonium Methosulfate, Dimethiconol, Lecithin, Sodium Citrate, Retinol, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Cholesterol, Phenoxyethanol, Alcohol, Isopropyl Myristate, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Pentylene Glycol, Phytosphingosine, Xanthan Gum, Polysorbate 20, Ethylhexylglycerin

Hyaluronic acid is a great skincare ingredient for all skin types, because it pulls moisture to the skin to help it maintain healthy hydration levels. The ceramides in this booster also help restore the moisture barrier and strengthen the skin.

In addition to the hydrating benefits, hyaluronic acid has been shown to help minimize the appearance of fine lines and wrinkles, making this booster a great choice for those looking for anti-aging benefits.

Water (Aqua), Glycerin (hydration/skin replenishing), Sodium Hyaluronate (hydration/skin replenishing), Hyaluronic Acid (hydration/skin replenishing), Ceramide NP (hydration/skin replenishing), Ceramide AP (hydration/skin replenishing), Ceramide EOP (hydration/skin replenishing), Phytosphingosine (hydration/skin replenishing), Yeast Extract (skin replenishing), Adenosine (skin-restoring), Cholesterol (skin replenishing), Panthenol (skin replenishing), Silanetriol (hydration), Butylene Glycol (hydration), Sodium Lauroyl Lactylate (hydration), Carbomer (texture-enhancing), Xanthan Gum (texture-enhancing), Citric Acid, Sodium Hydroxide, Polysorbate 20 (texture-enhancing), Ethylhexylglycerin (preservative), Phenoxyethanol (preservative)

This customer favorite booster contains nine non-fragrant, antioxidant-rich plant oils that alleviate dryness and calm the skin. It also contains ceramides, which further help restore the moisture barrier of the skin.

One of the key oils in this booster is jojoba oil, which is anti-inflammatory, can help restore the skin’s barrier, and has the ability to help fight the signs of aging. Another key ingredient in this blend is argan oil, a skin-softening oil that has been shown to improve elasticity and hydration.

Simmondsia Chinensis (Jojoba) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Carthamus Tinctorius (Safflower) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Prunus Armeniaca (Apricot) Kernel Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Helianthus Annuus (Sunflower) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Vaccinium Macrocarpon (Cranberry) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Argania Spinosa (Argan) Kernel Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Borago Officinalis (Borage) Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Oenothera Biennis (Evening Primrose) Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Echium Plantagineum Seed Oil (non-fragrant oil/skin-soothing/antioxidant/emollient), Ceramide NS (hydration/skin replenishing), Cholesterol (hydration/skin replenishing)

The unique, next-generation retinoid actives in this serum makes it one of the best The Ordinary products for those who want to use a retinol but are worried about irritation. Retinoids (vitamin A derivatives) are well-known for preventing and reducing the appearance of fine lines, wrinkles, and other signs of aging.

This product contains granactive retinoid, a complex of solubilized hydroxypinacolone retinoate (HPR). This form of retinoid offers anti-aging benefits without the irritation associated with retinol (which is also a vitamin A derivative). It also contains retinol that comes in a protective capsule to further prevent irritation, boost anti-aging benefits, and support the granactive retinoid.

Aqua (Water), Glycerin, Caprylic/Capric Triglyceride, Ethyl Linoleate, Propanediol, Dimethyl Isosorbide, Cetearyl Isononanoate, Bisabolol, Hydroxypinacolone Retinoate, Retinol, Tasmannia Lanceolata Fruit/Leaf Extract, Inulin Lauryl Carbamate, Glyceryl Stearate, Ceteareth-12, Ceteareth-20, Cetearyl Alcohol, Carrageenan, Xanthan Gum, Acacia Senegal Gum, Cetyl Palmitate, Sucrose Laurate, Polysorbate 20, Isoceteth-20, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, Behentrimonium Chloride, Trisodium Ethylenediamine Disuccinate, Disodium EDTA, Dehydroacetic Acid, Benzoic Acid, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Retinol is the gold-standard for minimizing wrinkles, fine lines, and hyperpigmentation. Those who are experienced with retinoid products may prefer the Retinol 1% in Squalane over the Granactive Retinoid 2% Emulsion, as it is more potent. However, with the higher strength comes a higher risk of irritation, so it is best suited for those who’ve used retinoid products in their routine.

This serum contains squalane and jojoba oil, two ingredients that hydrate and soothe the skin. They may help minimize the irritation caused by the retinol.

Squalane, Caprylic/Capric Triglyceride, Simmondsia Chinensis (Jojoba) Seed Oil, Retinol, Solanum Lycopersicum (Tomato) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydroxymethoxyphenyl Decanone, BHT.

Peptides are excellent for reducing wrinkles, improving the skin’s barrier, and promoting skin elasticity. This gel-like serum from The Ordinary pulls out all the stops with six peptide complexes for potent anti-aging benefits.

In addition to the peptide complexes, this serum contains 11 amino acids that help increase the skin’s hydration and further fight the signs of aging. It also contains multiple hyaluronic acid complexes, which attract moisture to the skin and reduce the appearance of fine lines.

Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

This serum is excellent for both minimizing the appearance of enlarged pores and reducing fine lines. Lipo-hydroxy acid (which is a derivative of salicylic acid) helps diminish the appearance of enlarged pores, while also brightening and evening tone and texture. Glycolic acid works on the surface of the skin to smooth texture and minimize lines.

In addition to the chemical exfoliators mentioned above, this serum contains hyaluronic acid, which keeps the skin hydrated and helps counteract the potentially drying effects of the exfoliators.

Water, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycolic Acid, Diisopopyl Adipate, Propylene Glycol, Pentylene Glycol, Citric Acid, Ppg-26-buteth-26, Peg-30 Glyceryl Cocoate, Peg-40 Hydrogenated Castor Oil, Sodium Hydroxide, P-anisic Acid, Hydrolyzed Hyaluronic Acid, Capryloyl Salicylic Acid, Tetrasodium Edta, Polyquaternium-10.

Vitamin C is an incredibly effective skincare ingredient that is known to boost collagen production, which in turn brightens, fades hyperpigmentation, and diminishes fine lines and wrinkles. This serum contains a potent 10% concentration of vitamin C (ascorbic acid), which will help even overall skin tone and texture.

In addition to ascorbic acid, this serum contains salicylic acid, which gently exfoliates, and hyaluronic acid and sodium hyaluronate, which draw moisture to the skin.

Aqua/Water/Eau, Ascorbic Acid, Cyclohexasiloxane, Glycerin, Alcohol Denat., Potassium Hydroxide, Polymethylsilsesquioxane, Polysilicone-11, Dimethicone, Propylene Glycol, Pentaerythrityl Tetraethylhexanoate, C13-14 Isoparaffin, Tocopherol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Adenosine, Acetyl Dipeptide-1 Cetyl Ester, Peg-20 Methyl Glucose Sesquistearate, Poloxamer 338, Salicylic Acid, Polyacrylamide, Toluene Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Bht, Laureth-7, Parfum/Fragrance.

Prevention is key when it comes to maintaining youthful skin, and this water-based serum sunscreen is an excellent choice. The SPF 50 protects the skin from the sun’s rays, which can contribute to premature aging. Additionally, the antioxidant blend protects against damaging free radicals that these UV rays cause.

The antioxidant blend in this sunscreen includes vitamin E, vitamin C, baicalin, and senna alata.

Active: Avobenzone 2.68% (sunscreen), Homosalate 9.60% (sunscreen), Octisalate 2.88% (sunscreen), Octocrylene 5.38% (sunscreen), Oxybenzone 3.46% (sunscreen). Inactive: Water, Dimethicone, Cyclopentasiloxane, Tocopherol, Acrylates/Dimethicone Copolymer, Phenoxyethanol, Propylene Glycol, Caprylyl Glycol, Silica, Sodium Polyacrylate, Ascorbyl Glucoside, Scutellaria Baicalensis Root Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Diethylhexyl Syringylidenemalonate, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Cassia Alata Leaf Extract, Maltodextrin, Triethanolamine.

Those looking to brighten their skin tone while also fighting against the signs of aging should turn to this product, which has the highest concentration of antioxidant-rich vitamin C of any of the products the brand offers. Since vitamin C has been shown to help with hyperpigmentation, this option is also great for those looking to even out dark spots. In addition to vitamin C, this product contains sodium hyaluronate (the sodium salt of hyaluronic acid), which increases moisture in the skin.

Since this product contains such a high percentage of vitamin C, some users may experience tingling as their skin adjusts, particularly if they’re newer to topical vitamin C.

Ascorbic Acid, Squalane, Isodecyl Neopentanoate, Isononyl Isononanoate, Coconut Alkanes, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Sodium Hyaluronate, Glucomannan, Coco-Caprylate/Caprate, Butylene/Ethylene/Styrene Copolymer, Acrylates/Ethylhexyl Acrylate Crosspolymer, Trihydroxystearin, BHT.

Retinol is the gold-standard for fighting signs of aging, so this is an excellent choice for those with wrinkles, fine lines, and sun spots. The addition of soothing and hydrating ingredients helps counteract some of the potential irritating side effects of retinol.

This serum contains vitamin C, which brightens the skin, as well as licorice extract and oat extract, which soothe and calm redness.

Water (Aqua), Dimethicone (skin-softening), Glycerin (skin-replenishing), Butylene Glycol (hydrating), Isononyl Isononanoate (emollient), Castor Isostearate Succinate (skin-softening ), Glyceryl Stearate (texture enhancer), C12-15 Alkyl Benzoate (emollient), Dimethicone Crosspolymer (texture enhancer), PEG-33 (stabilizer), Polysorbate 20 (texture enhancer), Behenyl Alcohol (texture enhancer), PEG-100 Stearate (texture enhancer), Pentaerythrityl Tetraisostearate (stabilizer), Polymethylsilsesquioxane (texture enhancer), Tetrahexyldecyl Ascorbate (vitamin C/antioxidant), Retinol (skin-restoring), Ceramide NG (skin-replenishing) , Palmitoyl Tetrapeptide-7 (skin-restoring), Palmitoyl Hexapeptide-12 (skin-restoring), Sodium Hyaluronate (skin-replenishing ), Dipotassium Glycyrrhizate (antioxidant plant extracts/skin-soothing), Glycyrrhiza Glabra Root Extract (licorice extract/antioxidant/skin-soothing), Avena Sativa Kernel Extract (oat extract/antioxidant/skin-soothing), Arctium Lappa Root Extract (burdock extract/antioxidant/skin-soothing), Salix Alba Bark Extract (willow bark extract/antioxidant/skin-soothing), Glycine Soja Sterols (antioxidant/skin-softening ), Lecithin (skin-restoring), Allantoin (skin-soothing), Tocopheryl Acetate (vitamin E/antioxidant), Hydrolyzed Soy Protein (antioxidant/skin-softening), Sorbitan Laurate (texture enhancer), Acetyl Dipeptide-1 Cetyl Ester (skin-soothing), Disodium EDTA (stabilizer), Hydroxyethylcellulose (texture enhancer), Palmitoyl Tripeptide-1 (skin-restoring), Sodium Hydroxide (pH adjuster), Tribehenin (emollient), Caprylyl Glycol (skin-softening), Ethylhexylglycerin (skin-softening), Pentylene Glycol (hydrating), PEG-75 Shea Butter Glycerides (emollient), PPG-12/SMDI Copolymer (stabilizer), PEG-10 Phytosterol (fatty acid-based emollient), PEG-8 Dimethicone (skin-softening), PEG-14 (texture enhancer), Magnesium Aluminum Silicate (texture enhancer), Arachidyl Glucoside (texture enhancer), Arachidyl Alcohol (texture enhancer), Sclerotium Gum (texture enhancer), Carbomer (gel-based texture enhancer), Phenoxyethanol (preservative), Benzoic Acid (preservative)

Vitamin C – an antioxidant that fights free radicals that can damage the skin – is key for a rounded out skincare routine, and this option is affordable and effective. It contains sodium ascorbyl phosphate, a stable form of vitamin C that doesn’t deteriorate as easily as other forms. It is able to brighten the skin and fight signs of aging, including fine lines, wrinkles, and dark spots.

In addition to vitamin C, this serum contains a blend of ingredients that hydrate, soothe, and nourish the skin, including hyaluronic acid, green tea leaf extract, rosehip oil, and aloe vera extract.

Purified Water, Glycerin (Vegetable Derived), Sodium Ascorbyl Phosphate (Vitamin C, Stay-C 50), Sodium Hyaluronate (Hyaluronic Acid), Organic Camellia Sinensis (Green Tea) Leaf Extract*, Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Alpha-Glucan Oligosaccharide (Vegetable Derived), Polymnia Sonchifolia (Yacon) Root Juice, Maltodextrin, Lactobacillus (Probiotic), Rosa Canina (Rosehip) Fruit Oil, Organic Aloe Barbadensis (Aloe Vera) Extract *, Allantoin, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Caprylic/Capric Triglyceride (Plant Derived), Ethylhexyl Palmitate, Xanthan Gum, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils

This lightweight serum is one of the best Paula’s Choice products, as it contains a powerful concentration of vitamin C, which evens out and brightens the skin tone while also minimizing fine lines and wrinkles. It also contains ingredients that hydrate and soothe the skin.

In addition to vitamin C, this serum contains ferulic acid and vitamin E. These antioxidants protect the skin, and are also known to increase the efficacy of vitamin C.

Water (Aqua), Ascorbic Acid (vitamin C/antioxidant), Butylene Glycol (solvent/texture enhancer), Ethoxydiglycol (solvent/texture enhancer), Glycerin (skin-replenishing), PPG-26-Buteth-26 (emulsifier/skin-softening), PEG-40 Hydrogenated Castor Oil (emulsifier/solubility enhancer), Pentylene Glycol (skin-softening slip agent), Tocopherol (vitamin E/stabilizing antioxidant), Sodium Hyaluronate (hydration), Hexanoyl Dipeptide-3 Norleucine Acetate (skin-restoring peptide), Lecithin (skin-restoring/hydration), Ferulic Acid (stabilizing antioxidant), Panthenol (vitamin B5/skin-softening, skin-soothing), Bisabolol (skin-soothing), Oryza Sativa (Rice) Bran Extract (skin-softening/chelating agent), Propyl Gallate (antioxidant), Sodium Gluconate (chelating agent), Sodium Hydroxide (pH adjuster), Phenoxyethanol (preservative), Ethylhexylglycerin (preservative)