You can find a ton of amazing skincare products at your local drugstore that target a variety of skin types and concerns. If you’re looking to add a new serum to your skincare routine, here are the best drugstore serums.
1. Hydrium Centella Aqua Soothing Ampoule
COSRX Serum for Soothing and hydrating
COSRX Hydrium Centella Aqua Soothing Ampoule
This soothing and hydrating serum is packed with effective yet gentle ingredients that help soothe the skin. It is even suitable for calming current breakouts.
2. Resurfacing Retinol Serum
CeraVe Serum for Fading post-inflammatory hyperpigmentation and minimizing large pores
CeraVe Resurfacing Retinol Serum
This drugstore retinol serum is specifically formulated to tackle post-inflammatory hyperpigmentation and large pores, and helps promote an overall even and clear complexion.
3. Hyaluronic Acid Booster
Paula's Choice Serum for Hydration
Paula’s Choice Hyaluronic Acid Booster
This serum combines hyaluronic acid with ceramides and other deeply hydrating ingredients to give the skin an extra moisture boost.
4. Moisture Renewal Oil Booster
Paula's Choice Serum for Extra Moisture
Paula’s Choice Moisture Renewal Oil Booster
This oil booster contains a blend of nourishing plant oils and renewing ceramides to help moisturize and revitalize dry skin.
5. Omega+ Complex Serum
Paula's Choice Serum for Strengthening the Skin’s Barrier and Hydration
Paula’s Choice Omega+ Complex Serum
This award-winning serum contains omega fatty acids and other replenishing ingredients that strengthen the skin’s barrier while reviving and hydrating the skin.
6. Azelaic Acid Suspension 10%
The Ordinary Serum for Fighting Acne and Evening Skin Tone
The Ordinary Azelaic Acid Suspension 10%
This product from The Ordinary hosts an impressive variety of benefits. Azelaic acid is a brightening skincare ingredient known for minimizing acne, lightening hyperpigmentation, and reducing redness.
7. Granactive Retinoid 2% Emulsion
The Ordinary Serum for Anti-Aging
The Ordinary Granactive Retinoid 2% Emulsion
This is a cult-favorite The Ordinary product, and one of the best for preventing and reducing the appearance of fine lines and wrinkles without the irritation often associated with traditional retinol.
8. Retinol 1% in Squalane
The Ordinary Serum for Fighting the Signs of Aging
The Ordinary Retinol 1% in Squalane
This product is the highest-strength retinoid serum from The Ordinary, and the brand’s answer to more traditional retinol products. It’s excellent for preventing and minimizing the signs of aging.
9. Caffeine Solution 5% + EGCG
The Ordinary Serum for Treating Dark Circles and Puffiness
The Ordinary Caffeine Solution 5% + EGCG
This eye serum contains a high concentration of caffeine to reduce pigmentation and puffiness around the eyes.
10. Buffet Serum
The Ordinary Serum for Fighting the Signs of Aging
The Ordinary “Buffet”
“Buffet” is a multi-purpose serum that combines a variety of peptide complexes, amino acids, and hyaluronic acids to address signs of aging.
11. 100% Plant-Derived Squalane
The Ordinary Serum for Lightweight Hydration
The Ordinary 100% Plant-Derived Squalane
This squalane product looks, feels, and acts similarly to a light oil, but is actually oil-free. It is excellent for adding an extra boost of hydration to your skincare routine.
12. Anti-Aging Pore Minimizer Face Serum
La Roche-Posay Serum for Minimizing Pores and Exfoliating
La Roche-Posay Effaclar Anti-Aging Pore Minimizer Face Serum
This serum is packed with chemical exfoliators and additional ingredients that help minimize the appearance of pores, while also smoothing the skin’s texture and reducing fine lines.
13. 10% Pure Vitamin C Serum
La Roche-Posay Serum for Hyperpigmentation and Wrinkles
La Roche-Posay 10% Pure Vitamin C Serum
This serum contains a potent concentration of vitamin C, which is known for its ability to brighten, diminish post-inflammatory hyperpigmentation, and even skin tone.
14. Antioxidant Serum with SPF 50 Sunscreen
La Roche-Posay Serum for Daily Sun Protection
La Roche-Posay Anthelios AOX Antioxidant Serum with SPF 50 Sunscreen
This product not only provides SPF protection to defend against UVA and UVB rays, but it also contains antioxidants to defend against free radicals that accelerate aging.
15. Pigmentclar Serum Visible Dark Spot Reducer
La Roche-Posay Serum for Hyperpigmentation
La Roche-Posay Pigmentclar Serum Visible Dark Spot Reducer
This dark spot corrector is one of the best La Roche-Posay products for acne scars, because it combines lipo-hydroxy acid with other brightening skincare ingredients that diminish dark spots.
16. Hyalu B5 Pure Hyaluronic Acid Serum
La Roche-Posay Serum for Hydration
La Roche-Posay Hyalu B5 Pure Hyaluronic Acid Serum
This serum combines pure hyaluronic acid with other hydrating ingredients that replenish the skin’s moisture barrier.
17. Vitamin C Suspension 23% + HA Spheres 2%
The Ordinary Serum for Evening Skin Tone and Fighting the Signs of Aging
The Ordinary Vitamin C Suspension 23% + HA Spheres 2%
This is one of the best The Ordinary products to add to your skincare routine, because it contains a potent concentration of vitamin C (ascorbic acid), which brightens and evens out overall skin tone while fighting the signs of aging.
18. Niacinamide 10% + Zinc 1%
The Ordinary Serum for Minimizing Blemishes and Controlling Sebum Production
The Ordinary Niacinamide 10% + Zinc 1%
This multi-tasking product helps minimize blemishes and congestion while reducing redness and regulating the production of sebum.
19. Hyaluronic Acid 2% + B5
The Ordinary Serum for Hydration
The Ordinary Hyaluronic Acid 2% + B5
This unique hyaluronic acid serum effectively attracts moisture to the skin to leave it feeling hydrated and plump.
20. 1% Retinol Treatment
Paula's Choice Serum for Hyperpigmentation and Wrinkles
Paula’s Choice Clinical 1% Retinol Treatment
This treatment combines retinol, a powerful anti-aging ingredient, with hydrating and brightening ingredients for an even, smooth skin tone.
21. Redness Relief Repairing Serum
Paula's Choice Serum for Redness
Paula’s Choice Calm Redness Relief Repairing Serum
This calming, lightweight serum helps to reduce redness while also hydrating and fighting the signs of aging.
22. 10% Niacinamide Booster
Paula's Choice Serum for Refining Pore Size and Improving Skin Tone
Paula’s Choice 10% Niacinamide Booster
This super light niacinamide product is one of the best Paula’s Choice serums. It delivers a multitude of benefits, including minimizing the appearance of pores, controlling sebum production, smoothing fine lines, reducing redness, and brightening.
23. 10% Azelaic Acid Booster
Paula's Choice Serum for Evening Tone and Texture
Paula’s Choice 10% Azelaic Acid Booster
This booster combines azelaic acid with other brightening ingredients that work together to fade post-acne marks, minimize blemishes, brighten, and even out tone and texture.
24. Vitamin C Concentrated Serum
Derma E Serum for Brightening and Anti-Aging
Derma E Vitamin C Concentrated Serum
This affordable vitamin C serum contains a stable and effective form of vitamin C, as well as additional ingredients that help hydrate and soothe the skin.
25. C15 Super Booster
Paula's Choice Serum for Brightening and Fighting Signs of Aging
Paula's Choice C15 Super Booster
The 15% concentration of pure vitamin C in this serum helps brighten the skin while reducing the appearance of fine lines and wrinkles.
Should you use a serum everyday?
Many serums can be used everyday. Using a serum on a daily basis may help you more quickly address your skin concerns. That said, some serums contain a higher concentration of ingredients that may not be suitable for daily use, and may cause irritation when used too frequently. Refer to the instructions on the product label to decide whether you should use that serum daily, and also consider how your skin reacts when using that serum. You may also choose to alternate between different serums each day if you’d like to add more than one serum to your routine.
At what age should you start using a face serum?
There really isn’t a bad age to start using a serum. If you have specific skin concerns you’d like to target, you can start using a serum that addresses those issues at any age.
What goes on first: serum or moisturizer?
You’ll want to apply your serum first, and then follow up with a moisturizer (and then sunscreen during the day). As a rule of thumb, you should apply thinner products first, and leave the thickest products for last.
The Bottom Line
No matter what your skin concerns may be, you’ll be able to find a drugstore serum that can help you tackle your issues. Consider adding some of the best drugstore serums to your routine to promote a healthy, glowing complexion.